grant
Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 21 Sept 2016Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years oldAffectAgeAirway DiseaseAllergic asthmaAreaAsthmaAsthma in ChildrenBacteroidesBiologicalBostonBronchial AsthmaC4 bC4bCCL7CCL7 geneChildChild DevelopmentChild HealthChild YouthChildhoodChildhood AsthmaChildren (0-21)ClinicalClinical DataComplement 4bComplement C4bDataData ElementDevelopmentDiseaseDisorderEnrollmentEnvironmentEnvironmental ExposureEpidemiologic MethodologyEpidemiologic MethodsEpidemiologic research methodologyEpidemiologic research methodsEpidemiological MethodsEpidemiological TechniquesEpidemiologyExtrinsic asthmaFEV1FEV1%VCForced Expiratory Volume 1 TestForced Expiratory Volume in 1 SecondFundingFutureGI microbiomeGWA studyGWASGeneticGenetic DiversityGenetic VariationGenomeGenotypeGlucosiduronatesGlucuronatesGoalsHealthHomolog of Drosophila TOLLInfant and Child DevelopmentInternationalInvestigatorsKnowledgeLeadershipLearningLifeMARCMCP-3MCP3Mendelian randomizationMethods EpidemiologyMethods in epidemiologyMicrobeMicrobiomicsMoraxellaNC28NasalNasal Passages NoseNational Institutes of HealthNeural DevelopmentNoseObesityOutcomePFT/FEV1ParticipantPathogenesisPathway interactionsPediatric asthmaPediatric cohortPhenotypePopulationPositionPositioning AttributePreventative interventionProtocolProtocols documentationPublic HealthPulmonary Function Test/Forced Expiratory Volume 1RegulationReportingResearchResearch PersonnelResearch ResourcesResearchersResourcesRespiratory System, Nose, Nasal PassagesRiskRoleSCYA7Single Base PolymorphismSingle Nucleotide PolymorphismSiteStatistical MethodsStreptococcusTLR4TLR4 geneTestingToll HomologueUnited States National Institutes of HealthWorkadiposityagesairway microbiomeatopic asthmabiologicchild adipositychild obesitychildhood adipositychildhood obesitycohortcorpulencedevelopmentaldigestive tract microbiomeenrollenteric microbiomeentire genomeepidemiologicepidemiologicalevidence baseextrinsic allergic asthmafull genomegastrointestinal microbiomegene locusgenetic locusgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusgut microbiomegut-associated microbiomeinnovateinnovationinnovativeinsightintervention for preventionintestinal biomeintestinal microbiomekidslung functionmicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome interventionmicrobiome researchmicrobiome sciencemicrobiome species compositionmicrobiome structuremicrobiome studiesmicrobiome therapeuticsmicrobiome therapymicrobiome treatmentmicrobiome-based interventionmicrobiome-based therapeuticmicrobiome-based therapymicrobiome-based treatmentnasal microbiomeneurodevelopmentneuron developmentneuronal developmentnovelobese asthmaobese childrenobesity developmentobesity during childhoodobesity in childrenobesity-associated asthmaobesity-related asthmaparticipant enrollmentpathwaypatient enrollmentpediatricpediatric obesitypreventpreventingprevention interventionpreventional intervention strategypreventive interventionprogramspulmonary functionrespiratory microbiomerespiratory tract microbiomesingle nucleotide variantsinonasal microbiomesocial rolesocial stressessocial stressorstatistic methodsstatisticstoll-like receptor 4whole genomewhole genome association analysiswhole genome association studywork groupworking groupyoungster
Description preview
Recent studies report probabilistic associations between the early-life microbiome and various child health outcomes (e.g., obesity, asthma), suggesting potential insights into pathogenesis and subsequent, targeted development of preventive interventions. However, the causal role of the early-life microbiome on child health remains unclear. Our…
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