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Host determinants of enterovirus RNA replication and in vivo neuropathogenesis

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years oldActinsAcuteAcute NasopharyngitisAcute PoliomyelitisAddressBiologyBody TissuesCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChildChild YouthChildren (0-21)Common ColdCommunicable DiseasesComplexCoxsackie VirusesCoxsackievirusCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyDNA mutationDataEC 2.1.1EV-68EV-71EV-A71EV-D68Electron CryomicroscopyEnteralEntericEnterovirusEnterovirus 68Enterovirus 71Enterovirus A71Enterovirus D68Enterovirus InfectionsFamily PicornaviridaeGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGenomeGoalsGrowthHealthHost FactorHost Factor ProteinHumanHuman poliovirusImmunityImmunocompetentIn VitroInfectionInfectious DiseasesInfectious DisorderInjectionsIntegration Host FactorsInvadedKnock-outKnockoutKnowledgeMedicalMethodsMethylationMethyltransferaseMiceMice MammalsModelingModern ManMolecularMurineMusMutationMyocarditisNS ProteinsNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurological ManifestationsNeurological Signs and SymptomsNeuropathogenesisOralPalsyParalysedPathogenesisPicornaviridaePicornavirusesPlayPlegiaPolioPolio VirusPoliomyelitisPoliovirusPolyproteinsProtein MethylasesProtein MethylationProtein MethyltransferasesProteinsProteomicsRNA VirusesRNA replicationRegulationRhinovirusRhinovirus infectionRoleSiteStructureSubcellular ProcessTestingTherapeutic InterventionTissue GrowthTissuesTranslationsTransmissionVeterinary MedicineViralViral DiseasesViral Nonstructural ProteinsViral PathogenesisViremiaVirusVirus DiseasesVirus Replicationacute flaccid myelitisasthma attackasthma exacerbationcardiac inflammationcell typecryo-EMcryoEMcryogenic electron microscopyexacerbation in asthmaexacerbation prone asthmaexacerbation prone asthmaticgenome mutationhuman diseaseimmune competentin vivoinfected with Rhinovirusinfection mouthinnate immune mechanismsinsightintervention therapykidsmembermethylasemicrobialmouse modelmurine modelneonateneuralneural manifestationnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetontogenyoral infectionoral infectiousparalysisparalyticpathogenpoliomyelitis virusscreeningscreeningssocial roletranslationtransmethylasetransmission processviraemiaviral RNAviral infectionviral multiplicationviral replicationviral sepsisvirus RNAvirus host interactionvirus infectionvirus multiplicationvirus pathogenesisvirus-induced diseasevirusemiayoungster

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PROJECT SUMMARY
Pathogens have evolved to co-opt cellular functions to support their replication and spread while inactivating
innate immune mechanisms that restrict their growth. Discovery and characterization of cellular components that
regulate pathogenesis hold promise for revealing new approaches to treat infectious diseases. Enteroviruses…

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