grant
Hormonal control of stem cells in the Drosophila ovary
Organization EAST CAROLINA UNIVERSITYLocation GREENVILLE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AddressBody TissuesBone Morphogenetic Protein GeneBone Morphogenetic ProteinsCell BodyCell Communication and SignalingCell CycleCell Cycle ProgressionCell Division CycleCell SignalingCell divisionCellsDrosophilaDrosophila genusDrosophila melanogasterEcdysoneEndocrineEndocrine Gland SecretionEndowmentEnsureFutureGene TranscriptionGeneticGenetic ModelsGenetic TranscriptionGoalsHormonalHormonesImageIntracellular Communication and SignalingKnowledgeLength of LifeLigandsLongevityM PhaseMitosisMitosis StageMolecularMolting HormoneNuclear ReceptorsOvarianOvaryPhysiologicPhysiologicalProductionProgenitor CellsRNA ExpressionReagentRegulationResearchResolutionSignal TransductionSignal Transduction SystemsSignalingSomatic CellSystemTherapeutic HormoneTherapeutic Steroid HormoneTissuesTranscriptionWorkbiological signal transductionbone morphogenic proteinecdysone receptorfruit flygene regulatory networkgerm stem cellsgermline progenitorgermline progenitor cellsgermline stem cellsimaginginsightneural cell bodyneuronal cell bodynovelpleiotropic effectpleiotropismpleiotropyprogenitor cell divisionprogenitor cell homeostasisprogenitor cell renewalprogenitor divisionprogenitor renewalprogramsresolutionsresponsesomaspatial and temporalspatial temporalspatiotemporalstem and progenitor cell divisionstem and progenitor cell renewalstem cell divisionstem cell homeostasisstem cell renewalstem cellsstem cells in the germlinesteroid hormonetissue repairtranscriptomics
Description preview
PROJECT SUMMARY/ABSTRACT
Stem cells endow tissues the ability to replace cells and maintain cellular diversity during remodeling or
damage. Stem cells depend on both hormones and local signaling to regulate their activity in response to
physiological demand. The molecular mechanisms by which this spatiotemporal regulation is achieved,
however, are…
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