grant
HIV Tat-associated Sensory Neuropathy and the Contribution of Toll-like Receptor Pathway
Organization UNIVERSITY OF NEW ENGLANDLocation BIDDEFORD, UNITED STATESPosted 19 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAffectAnimal ModelAnimal Models and Related StudiesAnimalsAnti-Retroviral AgentsAutopsyBehaviorBehavioralBioinformaticsCell BodyCellsChronic DiseaseChronic IllnessClinicalClinical assessmentsDataDetectionDevelopmentDiagnosisDoxycyclineDrug CombinationsDrug TherapyDrugsEffectivenessFDA approvedGMO AnimalsGene TranscriptionGenesGenetic TranscriptionGenetically Modified AnimalsGoalsHAARTHIVHIV InfectionsHIV-1HIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHealthHighly Active Antiretroviral TherapyHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1IRAKIRAK1IRAK1 geneImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIndividualInfectionInflammationInterleukin-1 Receptor-Associated Kinase 1InvestigationKnock-outKnockoutKnowledgeLAV-HTLV-IIILocationLumbar Portion of Spinal CordLumbar Spinal CordLumbar spinal cord structureLymphadenopathy-Associated VirusMediatingMedicationMiceMice MammalsModelingModern ManMurineMusNerve ConductionNeural ConductionNeurologicNeurologicalNeuropathyNon-Polyadenylated RNAOutcomePNS DiseasesPainPain ControlPain TherapyPain managementPainfulPathway interactionsPatientsPeripheral Nerve DiseasesPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPeripheral Sensory NeuropathyPersonal SatisfactionPersonsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPre-Clinical ModelPreclinical ModelsPrevalenceProcessPropertyProteinsPublishingQOCQuality of CareQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNARNA ExpressionRNA Gene ProductsRegulationRegulatory ProteinReportingResearch ResourcesResourcesRibonucleic AcidRoleSignal PathwaySignaling MoleculeTLR proteinTestingTimeToll-Like Receptor Family GeneToll-Like Receptor PathwayToll-like receptorsTrans-Acting FactorsTrans-ActivatorsTransactivatorsTranscriptionTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscriptional Activator/CoactivatorTransgenic MiceVariantVariationVibramycinVirus-HIValpha-6-Deoxyoxytetracyclineanti-retroviralbio-informatics toolbioinformatics toolchronic disorderco-morbidco-morbiditycomorbiditycytokinedevelopmentaldrug candidatedrug discoverydrug interventiondrug treatmentdrug/agentgenetic regulatory proteinimprovedin vivolife spanlifespanmodel of animalnanostringnecropsyneuropathicneuropathic painoverexpressoverexpressionpain interventionpain treatmentpainful neuropathypathwaypellepharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspostmortemqRTPCRreceptor bindingreceptor boundrecruitregulatory gene productsensory neuropathysocial rolesoundtreatment strategywell-beingwellbeing
Description preview
Summary
Peripheral neuropathies are the most frequent neurological complications associated with HIV, within which
HIV sensory neuropathy (HIV-SN) is the most common form, affecting nearly half of HIV/AIDS patients with the
prevalence ranging from 1.2 – 69.4%. HIV-SN frequently manifests with hard-to-manage pain and is often
under-diagnosed and/or…
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