grant
HIV reverse transcriptase structure, function, inhibition, and roles in viral assembly and maturation
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 1 Nov 1988Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AIDS VirusAIDS/HIVAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressArchitectureAreaAssayBindingBinding SitesBioassayBiochemicalBiological AssayBiologyBiophysicsCell BodyCell DeathCellsCollaborationsCombining SiteComplexCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyDBL OncoproteinDNADNA ReplicationDNA SynthesisDNA biosynthesisDataDeoxyribonucleic AcidDevelopmentDimerizationDouble-Stranded DNADouble-Stranded RNADrugsEC 2.7.7.49Electron CryomicroscopyElongation FactorEngineeringEngineering / ArchitectureEnzyme GeneEnzymesEsteroproteasesEukaryotic protein translationGrantGripsHIVHIV InfectionsHIV cureHIV functional cureHIV interventionHIV replicationHIV therapeuticHIV therapyHIV treatmentHIV viral infectionHIV viral replicationHIV virus infectionHIV-1HIV-1 cureHIV-1 functional cureHIV-1 infectionHIV-1 interventionHIV-1 replicationHIV-1 therapeuticHIV-1 therapyHIV-1 treatmentHIV-1 viral replicationHIV-1 virus replicationHIV-IHIV/AIDSHIV/AIDS cureHIV1HealthHeterogeneityHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus therapyHuman Immunodeficiency Virus treatmentHuman Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1In VitroInfection by HIV-1Infection from HIV-1Infection of HIV-1InvestigatorsKnowledgeLAV-HTLV-IIILengthLettersLymphadenopathy-Associated VirusLysine-Specific tRNAMapsMarylandMedicationMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular ProbesMolecular StereochemistryNIAIDNNRTINational Institute of Allergy and Infectious DiseaseNational Institutes of HealthNon-Polyadenylated RNANucleic AcidsNucleosidesNucleotidesOutcomePatientsPeptidasesPeptide HydrolasesPharmaceutical PreparationsPhasePolymerasePolyproteinsPredispositionProcessProtease GeneProteasesProtein DimerizationProtein Translation PathwayProteinasesProteinsProteolytic EnzymesPublicationsRNARNA Gene ProductsRNA TranscriptaseRNA-Dependent DNA PolymeraseRNA-Directed DNA PolymeraseReactive SiteResearchResearch PersonnelResearchersResistanceReverse TranscriptaseReverse TranscriptionRevertaseRibonucleic AcidRoleScientific PublicationSeriesSingle Crystal DiffractionStructureSusceptibilityTechnologyTestingTherapeuticTherapeutic InterventionThumbThumb structureTimeTranscription InitiationTranslationsUnited States National Institutes of HealthViralViral reservoirVirionVirus AssemblyVirus ParticleVirus ReplicationVirus reservoirVirus-HIVVisualizationWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyactive followupbiophysical foundationbiophysical principlesbiophysical sciencescell killingconformationconformationalconformational conversionconformational stateconformational transitionconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydata depositiondata submissiondevelopmentaldimerdrug/agentds-DNAdsDNAdsRNAefavirenzenhancing factorfightingfollow upfollow-upfollowed upfollowupfundamental researchgrasphigh definitionhigh-resolutionhuman immunodeficiency virus curehuman immunodeficiency virus infectionhuman immunodeficiency virus replicationhuman immunodeficiency virus-1 replicationimprovedinfected with HIVinfected with human immunodeficiency virusinhibitorinnovateinnovationinnovativeinsightintervention therapymonomermutantnecrocytosisnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynon-nucleoside RT inhibitorsnon-nucleoside reverse transcriptase inhibitorsnonnucleoside reverse transcriptase inhibitorsnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnucleic acid structureoncogene protein DBLp66pol Gene Productspol Polyproteinspol Proteinprospectiveprotein DBLprotein expressionprotein structureprotein structuresproteins structureprototyperesistantsocial rolestructural biologytRNALystranslationtreat HIVtreat Human Immunodeficiency Virusviral assemblyviral multiplicationviral replicationvirus multiplication
Description preview
Project Abstract
HIV remains a key health challenge, with fundamental aspects of the viral replication machinery remaining
poorly understood. Building on our extensive studies of HIV-1 reverse transcriptase (RT) structure and
function, we propose to further investigate RT’s roles within the reverse transcription complex (RTC) and the
viral…
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