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HIV immune evasion and escape through T cell virological synapses

Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Nov 2024Deadline 31 Mar 2025 ⚠️
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusBackCell BodyCell Communication and SignalingCell SignalingCell surfaceCellsDevelopmentDorsumEsteroproteasesExclusionGolgiGolgi ApparatusGolgi ComplexHIVHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV env Protein gp120HIV envelopeHIV envelope proteinHTLV-III gp120Human Immunodeficiency VirusesImmune EvasionIndividualInfectionIntracellular Communication and SignalingLAV-HTLV-IIILymphadenopathy-Associated VirusMetabolic GlycosylationMolecular ConfigurationMolecular ConformationMolecular StereochemistryPeptidasesPeptide HydrolasesProcessProductionProtease GeneProteasesProteinasesProteinsProteolytic EnzymesProtomerRecyclingSignal TransductionSignal Transduction SystemsSignalingSortingT-CellsT-LymphocyteTranslatingViralVirionVirus ParticleVirus-HIVbiological signal transductionconformationconformationalconformational stateconformationallyconformationsdevelopmentalglycosylationgp120gp120 ENV Glycoproteingp120(HIV)gp160immune evasiveneutralizing antibodyparticlethymus derived lymphocytetraffickingvirological synapse

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Description preview

Summary
Understanding the conformational states of the HIV Envelope (Env) protein that bNAbs target is critical

because these are most effective at blocking infection. Env is Translated as a 160 kD precursor, cleaved, and

glycosylated in the Golgi before being trafficked to the cell surface, where it is incorporated into virus particles

and…

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HIV immune evasion and escape through T cell virological synapses — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | UNITED STA | Dev Procure