High Throughput Synthesis of PROTACs to target tyrosine kinases in human platelets.

The key objective of this research is to conduct efficient synthesis of proteolysis targeting chimeras (PROTACs) for the targeted degradation of kinases in human platelets.

Proteolysis-targeted chimeras (PROTACs) are a rapidly developing modality within drug discovery which utilise endogenous proteasomal degradation pathways to target proteins…