grant
High-throughput, single-molecule sequence analysis of virus populations in vivo
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAnti-HIV resistanceAnti-HIV resistantAnti-viral ResponseAnti-viral TherapyAntibody ResponseBase PairingBioinformaticsClinicalComplexDNA mutationDiseaseDisorderDrug resistance in HIVEvolutionGene ProteinsGene TargetingGene variantGenerationsGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationGoalsHIVHIV drug resistanceHIV drug resistantHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHumanHuman Immunodeficiency VirusesImmune responseIndividualInfluenza VirusInterventionLAV-HTLV-IIILaboratoriesLengthLymphadenopathy-Associated VirusMediatingMedicalMethodsModern ManMutationOutcomePersonsPopulationPopulation HeterogeneityProtein Gene ProductsSEQ-ANSamplingSequence AnalysesSequence AnalysisTherapeuticVariantVariationViralViral GenomeVirusVirus ReplicationVirus-HIVWorkallelic variantdiverse populationsdrug resistant HIVgenetic analysisgenetic variantgenome mutationgenomic variantheterogeneous populationhigh throughput technologyhost responseimmune system responseimmunoresponsein vivoinfluenzavirusinsightlong read seqlong-read sequencinglong-read transcript sequencinglow-frequency mutationneutralizing antibodynovelpopulation diversityrare allelerare mutationrare variantresistance to HIV drugresistance to anti-HIVresistant to HIV drugseasonal coronavirusseasonal human coronavirussingle moleculeviral infectious disease treatmentviral multiplicationviral replicationvirus genomevirus multiplication
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Description preview
Viruses that infect humans and cause disease exist in vivo as quasispecies of related but non-identical genetic variants. These quasispecies can arise by diversification of a small number of founder variants in an individual by the progressive accumulation of non-deleterious random mutations during ongoing rounds of virus replication. The…
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