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High-Throughput In Vitro Analyses of Trauma-Induced Tauopathy

Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AffectAxonCell BodyCell Culture TechniquesCellsCraniocerebral InjuriesCraniocerebral TraumaDataDegenerative Neurologic DisordersDendritic SpinesDevicesDrug ScreeningDrug TherapyDrugsDysfunctionFunctional disorderGoalsHead InjuriesHead TraumaHigh Throughput AssayImageIn VitroInfrastructureInjuryLinkMT-bound tauMTBIMeasuresMechanicsMedicationMethodsMiceMice MammalsMicro-tubuleMicrotubulesModelingMurineMusNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurological DamageNeurological InjuryNeurological traumaNeuronal InjuryNeuronsOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatients with traumatic brain injuryPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePharmacological TreatmentPharmacotherapyPhysiopathologyStretchingSwellingSynapsesSynapticSystemTBI PatientsTauopathiesTestingTraumaTraumatic encephalopathyWorkcell culturecell cultureschronic traumatic encephalopathydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdendrite spinedesigndesigningdrug discoverydrug interventiondrug treatmentdrug/agentefficacy testingexperimentexperimental researchexperimental studyexperimentsfluorescence imagingfluorescent imaginghigh throughput screeningimagingin vitro Modelinhibitorinjuriesinsightmachine learned algorithmmachine learning algorithmmachine learning based algorithmmechanicmechanicalmicrotubule bound taumicrotubule-bound taumild TBImild brain traumamild traumatic brain injuryneurodegenerative illnessneuron injuryneuronalneuropathologic tauneuropathological tauneurotraumapatch clamppathophysiologypatient oriented outcomespharmaceuticalpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsscale upscreeningscreeningssynapsetautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytraumatic brain injury patientsΟ„ Proteins

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PROJECT SUMMARY
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
repeated mild traumatic brain injury (TBI). CTE is among the many neurodegenerative diseases
characterized as tauopathies, wherein the protein tau, which is usually associated with
microtubules in the axons of neurons, becomes separated from…

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High-Throughput In Vitro Analyses of Trauma-Induced Tauopathy β€” UNIVERSITY OF MINNESOTA | UNITED STATES | Apr 2023 | Dev Procure