grant
High-throughput Discovery of Antibodies against Understudied Membrane Proteins using mRNA
Organization INTEGRAL MOLECULARLocation PHILADELPHIA, UNITED STATESPosted 1 May 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AbbreviationsAddressAffinityAnimalsAntibodiesAntigensBacteriophagesBindingBiologyBiomedical ResearchBlood SerumCatalogsCell surfaceChickensClinical Treatment MoabClinical TrialsComplexDevelopmentDiagnosticDrugsEnsureFDA approvedFamilyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGallus domesticusGallus gallusGallus gallus domesticusGenesGenomeHealthHumanHuman GenomeImmunizationImmunizeImmunoblottingImmunofluorescenceImmunofluorescence ImmunologicIndividualIndustryIon ChannelIonic ChannelsLipid BilayersMedicationMembraneMembrane ChannelsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMessenger RNAMiceMice MammalsModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonoclonal AntibodiesMurineMusNational Institutes of HealthPhage DisplayPhagesPharmaceutical PreparationsPhaseProcessProteinsProteomeProtocolProtocols documentationPublic HealthRNA immunizationRNA vaccinationReagentRecombinantsReproducibility of FindingsReproducibility of ResultsResearchSerumSpecificitySurface ProteinsSystemTechnologyTestingTherapeuticUnited States National Institutes of HealthVirus-like particleWestern BlottingWestern Immunoblottingbacterial viruscatalogcommercializationconformationconformationalconformational stateconformationallyconformationsdevelopmentaldrug/agentdruggable targetexperimentexperimental researchexperimental studyexperimentsflow cytophotometryhigh standardhuman diseasehuman whole genomeimmunocytochemistryimmunogenlipid bilayer membranemAbsmRNAmRNA immunizationmRNA vaccinationmembrane structuremonoclonal Absnew approachesnovel approachesnovel strategiesnovel strategyprogramsprotein blottingprotein purificationsuccessvirus-like nanoparticlesviruslike particle
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ABSTRACT
Of the 20,000 genes in the human genome, approximately 4,000 are considered “druggable”. However, less
than 10% of these druggable proteins are actually targeted by FDA-approved drugs. In 2014, the Illuminating
the Druggable Genome (IDG) project was launched by the NIH to address the large number of druggable
targets with high therapeutic…
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