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High-sensitivity tongue swab testing for tuberculosis

Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 20 Jun 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025ArchivesBacillusBiologicalBiomassCaringCell BodyCellsClinicalClinical ResearchClinical StudyCollectionCommunitiesDNADataDeoxyribonucleic AcidDetectionDiagnosisEvaluationFutureGrantHumanIncentivesIndividualInstitutionInvestigatorsJob LocationJob PlaceJob SettingJob SiteLaboratoriesLung TBLung TuberculosisM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMethodsModern ManMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNucleic Acid Amplification TestsNucleic Acid TestingOralOral TuberculosisPainlessPatientsPersonsPreparationPrevalenceProcessProtocolProtocols documentationPulmonary TBPulmonary TuberculosisReference StandardsResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk FactorsRunningSamplingSouth AfricaSputumSurvey InstrumentSurveysSwabSymptomsTB diagnosisTB infectionTechnologyTestingTongueTransmissionTuberculosisTuberculosis diagnosisUse EffectivenessViscosityWork LocationWork PlaceWork-SiteWorkplaceWorksitebiologiccase findingcommunity settingcost effectivenessdesigndesigningdetection sensitivitydetermine efficacydiagnosed with TBdiagnosed with Tuberculosisdisseminated TBdisseminated tuberculosiseffectiveness usingefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyfightinghealth care settingshigh risk grouphigh risk individualhigh risk peoplehigh risk populationimprovedinfection due to Mycobacterium tuberculosismtbnon-painfulnonpainfulnot painfulnoveloral TBpathogenpoint of carepreparationsresponsescreeningscreeningstongue dorsumtransmission processtuberculosis infectiontuberculous spondyloarthropathywork settingworker safetyworkforce safety

Applications closed.

Description preview

This project will enable high-sensitivity testing of noninvasive oral swab samples for diagnosis of active
tuberculosis (TB). Pulmonary TB is usually detected by analysis of sputum, a viscous material from human
airways. Sputum collection presents exposure risks and many patients cannot routinely produce sputum for
testing, especially in community…

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