grant
High resolution inflammatory networks induced by HIV reservoirs in adolescents
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years old3-D3-D modeling3-Dimensional3D3D modelingAIDS VirusAIDS testAIDS/HIV testAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdolescentAdolescent HIVAdolescent YouthAdultAdult HumanAgeAlgorithmsAntibodiesAutomobile DrivingBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCas nuclease technologyCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsChildChild YouthChildhoodChildren (0-21)ChronicClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommunicationComplementComplement ProteinsCoupledDiseaseDisease ProgressionDisorderEnvironmentFaceGene ExpressionGene TranscriptionGenesGenetic TranscriptionGoalsHIVHIV InfectionsHIV infection in adolescenceHIV infections in adolescentsHIV testHIV-1 testHIV-2 testHIV-infected (HIV+) adolescentsHIV-infected adolescentsHTLV-III InfectionsHTLV-III-LAV InfectionsHeart VascularHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus testImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIndividualInfectionInflammationInflammatoryInflammatory ResponseIntracellular Communication and SignalingKenyaLAV-HTLV-IIILifeLymphadenopathy-Associated VirusLymphatic TissueLymphoidLymphoid TissueMapsMetabolicMethodsModelingModern ManNeurocognitiveNon-Polyadenylated RNAOrganoidsPBMCPathologyPathway interactionsPerinatalPeripartumPeripheral Blood Mononuclear CellPopulationProteinsProvirus IntegrationRNARNA ExpressionRNA Gene ProductsResearch ResourcesResidualResidual stateResolutionResourcesRibonucleic AcidRiskRoleSamplingShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSiteSmall Interfering RNASourceStructureSystemT4 CellsT4 LymphocytesTechniquesTestingTissuesTranscriptionTransfectionValidationViralViral BurdenViral GenesViral LoadViral Load resultVirusVirus ReplicationVirus-HIVVulnerable Populationsadolescents living with HIVadolescents with HIVadulthoodagesantiretroviral therapyantiretroviral treatmentbiobankbiological signal transductionbiorepositorycell typecirculatory systemcohortcomplementationdrivingfacesfacialimmune activationin vivoinflammatory modulationinhibitorinsightjuvenilejuvenile humankidslatent HIV reservoirlatent HIV-1 reservoirlatent HIV1 reservoirnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypediatricpediatric HIV diseasepediatric HIV infectionpediatric human immunodeficiency virus diseasepediatric human immunodeficiency virus infectionperinatal HIVresolutionsscRNA sequencingscRNA-seqsecondary lymph organsecondary lymphatic organsecondary lymphoid organsexsiRNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial roletherapeutic evaluationtherapeutic testingthree dimensionalthree-dimensional modelingvalidationsviral multiplicationviral replicationvirus multiplicationvulnerable groupvulnerable individualvulnerable peopleyoungster
Description preview
Modified Project Summary/Abstract Section
Antiretroviral treatment (ART) for HIV infection effectively blocks viral replication, but fails to eradicate the virus, which can be a source of persistent inflammation. The pathways by which chronic, treated HIV infection drives inflammation are poorly defined, particularly in children and adolescents…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click