grant
High-dimensional chemical targeting of multiple neuron types to regulate energy balance
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Sept 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20252-photon3-D3-Dimensional3DAffectAnimal ModelAnimal Models and Related StudiesArcuate NucleusAreaBody WeightBody Weight decreasedBrainBrain Nervous SystemCalciumChemicalsClinical ResearchClinical StudyDiabetes MellitusDrug DesignDrug TargetingDrug TherapyDrugsEatingEncephalonFeeding behaviorsFood IntakeFutureGLP-1 receptorGLP-I receptorGene TranscriptionGenetic TranscriptionHigh Fat DietHumanHypothalamic structureHypothalamusImageInfundibular NucleusIngestive BehaviorLeannessLigandsMC4 ReceptorMedicationMelanocortin 4 ReceptorMiceMice MammalsModern ManMolecularMurineMusNausea and VomitingNerve CellsNerve UnitNeural CellNeurocyteNeuronsObese MiceObesityParaventricular Hypothalamic NucleusPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyPolypharmacyRNA ExpressionReceptor ProteinReceptor, Melanocortin, Type 4RegulationSatiationSingle cell seqSliceStructure of nucleus infundibularis hypothalamiTestingThinnessTimeTranscriptionWeight LossWeight Reductionadiposityawakebody weight losscell typecombinatorialcorpulencediabetesdiet-associated obesitydiet-induced obesitydiet-related obesitydrug interventiondrug treatmentdrug/agenteat lessenergy balancefeedingfeeding-related behaviorsgenetic approachgenetic strategyglucagon-like peptide-1 receptorhigh dimensionalityhigh rewardhigh riskhypothalamicimagingmachine learned algorithmmachine learning algorithmmachine learning based algorithmmachine learning based methodmachine learning methodmachine learning methodologiesmodel of animalmouse modelmurine modelneuralneural controlneural regulationneuromodulationneuromodulatoryneuronalneuroregulationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynutrient intake activityob/ob mouseoptogeneticsparaventricular nucleuspharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsreceptorreceptor expressionreduced eatingreduced food intakesatietyside effectsingle cell next generation sequencingsingle cell sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthree dimensionaltooltwo-photonwt-loss
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Summary
Recent drugs for treating obesity and diabetes, while promising, have major side effects. For example, drugs
that reduce food intake by targeting the melanocortin-4 receptor (MC4R) or the glucagon-like peptide-1 receptor
(GLP1R) induce side effects such as nausea and vomiting. Several drugs targeting these receptors likely act in
part via…
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