grant
Heterosynaptic mechanisms driving elevated synaptic inhibition and plasticity impairments following ischemia.
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 7 May 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026Ammon HornAsystoleAutomobile DrivingBehaviorBindingBiochemistryBiological ChemistryBrain Vascular TraumaBrain regionCaM KIICaM PK IICaM kinase IICaMKIICalciumCardiac ArrestCardiopulmonary ResuscitationCell Communication and SignalingCell SignalingCerebral IschemiaCerebrovascular TraumaChemosensitizationChemosensitization/PotentiationChronicCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunicationConnector NeuronCornu AmmonisDataDendritesDendritic SpinesDisturbance in cognitionDysfunctionElectrophysiologyElectrophysiology (science)Excitatory SynapseExhibitsFunctional disorderGeneticGlutamatesGoalsHeart ArrestHippocampusHourImageImpaired cognitionImpairmentInhibitory SynapseIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingIschemiaL-GlutamateLearningLong-Term PotentiationMediatingMemoryMemory DeficitMemory impairmentMiceMice MammalsMicroscopyMolecularMolecular InteractionMurineMusNerve CellsNerve UnitNeural CellNeural TransmissionNeurocyteNeuronsNeurophysiology / ElectrophysiologyOutcomeOutputPatientsPeptidesPhysiopathologyPotentiationPublishingPyramidal CellsPyramidal neuronReceptor ProteinReporterRodent ModelRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSliceSpecificitySpinal ColumnSpineStimulusStructureSurfaceSurvivorsSynapsesSynapticSynaptic ReceptorsSynaptic TransmissionSynaptic plasticityTestingTherapeuticTherapeutic InterventionTransmissionVascular Brain InjuryVertebral columnbackbonebiological signal transductioncalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcardiac resuscitationcerebral vascular injurycerebrovascular injurycognitive dysfunctioncognitive lossdendrite spinedrivingelectrophysiologicalexcitotoxicexcitotoxicityextracellulargephyringlutamatergicheart resuscitationhigh definitionhigh-resolutionhippocampalhippocampal pyramidal neuronimagingimaging approachimaging based approachimprovedin vivoinhibitorintervention therapymemory dysfunctionmulti-photon imagingmultiphoton imagingnerve cell deathnerve cell lossneural circuitneural circuitryneurocircuitryneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal excitabilityneuronal lossneuronal survivalneurorestorationneurorestorativenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoptogeneticspathophysiologypharmacologicpostsynapticreceptorresponsescaffoldscaffoldingsocial rolesuperresolution imagingsynapsesynapse functionsynapse inhibitionsynaptic circuitsynaptic circuitrysynaptic functionsynaptic inhibitiontooltransmission process
Description preview
Heterosynaptic mechanisms driving elevated synaptic inhibition and plasticity impairments following cardiac
arrest
GABAergic inhibitory synapses innervate pyramidal neurons and are crucial for controlling neuronal firing and
excitability. Synaptic inhibition profoundly influences the efficacy of excitatory synaptic transmission, by
regulating…
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