grant
Heparin-free extracorporeal circulation via combined nitric oxide releasing/generating surfaces
Organization UNIVERSITY OF GEORGIALocation ATHENS, UNITED STATESPosted 1 May 2021Deadline 31 Oct 2026
NIHUS FederalResearch GrantFY2024AddressAdhesionsAirway failureAnti-Bacterial AgentsAnticoagulationAttentionBacteriaBacterial InfectionsBindingBleedingBloodBlood Coagulation DisordersBlood DiseasesBlood PlateletsBlood Reticuloendothelial SystemBlood VesselsBlood-Borne PathogensBloodborne PathogensC albicansC. albicansC.albicansCOVID crisisCOVID epidemicCOVID infected patientCOVID pandemicCOVID patientCOVID positive patientCOVID-19COVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 infected patientCOVID-19 pandemicCOVID-19 patientCOVID-19 periodCOVID-19 positive patientCOVID-19 public health crisisCOVID-19 yearsCOVID19 patientCOVID19 positive patientCV-19Candida albicansCannulasCathetersCell BodyCell LineCellLineCellsClinicalClottingCoagulationCoagulation DisorderCoagulation ProcessCoagulopathyComplicationCoronavirus Infectious Disease 2019Critical IllnessCritically IllDataDevicesDomestic RabbitEmbolismEmbolusEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideExhibitsExtracorporeal CirculationExtracorporeal Membrane OxygenationFormulationGenerationsGoalsHeart failureHematologic DiseasesHematological DiseaseHematological DisorderHemodialysesHemodialysisHemorrhageHeparinHeparinic AcidHospital InfectionsHospital acquired infectionHypercoagulabilityImmobilizationIn VitroInfectionLeadLegal patentLifeMarrow plateletMeasuresMechanical ventilationMicrobial BiofilmsModelingMolecular InteractionMononitrogen MonoxideN-acetylpenicillamineNitric OxideNitric Oxide DonorsNitrogen MonoxideNitrogen ProtoxideNosocomial InfectionsObstructionOryctolagus cuniculusOxygenatorsP aeruginosaP. aeruginosaPatentsPatient AdmissionPatient CarePatient Care DeliveryPatientsPb elementPlatelet ActivationPlateletsPolymersPreventionPropertyPseudomonas aeruginosaPseudomonas pyocyaneaPulmonary ThromboembolismR-Series Research ProjectsR01 MechanismR01 ProgramRabbitsRabbits MammalsReportingResearch GrantsResearch Project GrantsResearch ProjectsRespiratory FailureRiskS aureusS epidermidisS-NitrosothiolsS. aureusS. epidermidisSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 infected patientSARS-CoV-2 pandemicSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSafetySe elementSeleniumSepsisSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicStaph aureusStaphylococcus aureusStaphylococcus epidermidisSterilizationStrains Cell LinesSurfaceSystemTechnologyTestingTherapeuticThrombocytesThrombophiliaThrombosisThrombusTimeTranslationsTubeVascular Endothelial CellWorkanalytical methodanti-bacterialanti-microbialantimicrobialbacteria infectionbacterial diseasebiofilmbleeding disorderblood disorderblood infectionblood lossbloodstream infectioncardiac failurecare for patientscare of patientscaring for patientscatalystclinical applicabilityclinical applicationclinical developmentclotting disordercoronavirus disease 2019coronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 infected patientcoronavirus disease 2019 pandemiccoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease infected patientcoronavirus disease pandemiccoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 patientcoronavirus infectious disease-19coronavirus patientcovalent bondcultured cell lineearly clinical trialearly phase clinical trialendothelial cell derived relaxing factorheavy metal Pbheavy metal leadhemocompatibilityhigh riskimprovedin vitro Bioassayinfection rateinstitutional infectionmechanical respiratory assistmechanically ventilatedorthopedic freezingpatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2polydimethylsiloxanepolymerpolymericpreventpreventingrate of infectionsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsuccesssynergismthromboembolic complicationsthrombogenesisthrombogenicitythrombosis complicationsthrombotic complicationsthrombotic diseasethrombotic disordertranslationvascular
Description preview
Project Summary/Abstract
The major limiting factors to clinical applications of blood-contacting materials, ranging from small catheters to
large extracorporeal circulation (ECC) devices, include platelet activation leading to thrombosis and infection.
Thrombus formation can further lead to obstruction of blood vessels, device malfunction, or even…
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