grant
Hemopexin as an Early Biomarker of Anthracycline Cardiac Toxicity
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2027
NIHUS FederalResearch GrantFY202614-HydroxydaunomycinActive OxygenAddressAdriablastinAdriablastineAdriacinAdriamycin PFSAdriamycin RDSAdriamycineAdriblastinAdriblastinaAdriblastineAdrimedacAffinityAlgorithmsAnthracyclineAssayBindingBioassayBiodistributionBiologicalBiological AssayBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBrainBrain Nervous SystemBreast CancerBreast Cancer PatientBreast Cancer therapyBreast Tumor PatientCancer BiologyCancer TreatmentCancersCardiacCardiac ToxicityCardiomyopathiesCardiotoxicCardiotoxicityCardiovascular DiseasesChemicalsChronicCollaborationsCytotoxic ChemotherapyCytotoxic TherapyDOXO-CELLDataDedicationsDiagnosisDoseDoxolemDoxorubicinDoxorubicinaDoxorubinDrug Metabolic DetoxicationDrug Metabolic DetoxificationELISAEchocardiogramEchocardiographyEncephalonEnzyme-Linked Immunosorbent AssayFarmiblastinaFe elementFe metabolismFe overloadFemaleFerroprotoporphyrinGeneticGerminoblastic SarcomaGerminoblastomaGlycoproteinsHO-1 enzymeHO1HO2HSP32HandHeartHeart InjuriesHeart failureHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHemeHemopexinHumanHydroxyl DaunorubicinHydroxyldaunorubicinImaging ProceduresImaging TechnicsImaging TechniquesInflammationInflammatoryInstitutionIntermediary MetabolismInvestigationIronIron OverloadIsraelKO miceKineticsKnock-out MiceKnockout MiceLiposomal AdriamycinLiverLymphomaMacrophageMalignant Breast NeoplasmMalignant Hematologic NeoplasmMalignant LymphomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Soft Tissue NeoplasmMalignant TumorMeasuresMediatingMedical centerMetabolic Drug DetoxicationsMetabolic ProcessesMetabolismMetabolism of Toxic AgentsMiceMice MammalsModern ManMolecularMolecular InteractionMurineMusMyocardial DiseasesMyocardial DisorderMyocardial depressionMyocardial dysfunctionMyocardiopathiesMφNatriuretic Peptide HormonesNatriuretic PeptidesNeurohormonesNull MouseOncologyOncology CancerOxidative StressOxygen RadicalsPathogenesisPathway interactionsPatientsPhenotypePhysiologicPhysiologicalPilot ProjectsPlasmaPlasma ProteinsPlasma SerumPro-OxidantsPrognosisProteinsProteomicsProtohemeReactive Oxygen SpeciesRecyclingReticuloendothelial SystemReticuloendothelial System, Serum, PlasmaReticulolymphosarcomaRiskRodent ModelRoleRubexSarcomaSpleenSpleen Reticuloendothelial SystemStressToxic effectToxicitiesTransthoracic EchocardiographyTreatment ProtocolsTreatment RegimenTreatment ScheduleTroponinWild Type MouseWomen's cohortWorkadriamycinanti-cancer therapyaptamerbio-markersbiobankbiologicbiologic markerbiomarkerbiomarker identificationbiorepositorycancer therapycancer-directed therapycardiac dysfunctioncardiac failurecardiac functioncardiac injurycardioprotectantcardioprotectioncardioprotectivecardiovascular disorderchemotherapyclinical validationcohortcohort in womencohort on womencost effectivedetoxificationearly biomarkersearly detection biomarkersearly detection markerseffective therapyeffective treatmentenzyme linked immunoassayfemale cohortfemale treatmentferrohemefunction of the hearthandsheart dysfunctionheart functionheart sonographyheme oxygenase-1heme-binding proteinhemeoxygenase 1hemin-binding proteinshepatic body systemhepatic organ systemidentification of biomarkersidentification of new biomarkersimprovedindividuals with breast cancerinsightiron metabolismleukemialoss of functionmalemalignancymalignant breast tumormalignant soft tissue tumormarker identificationmedical collegemedical schoolsmouse modelmultidisciplinarymurine modelmyocardium diseasemyocardium disorderneoplasm/cancerneuroendocrine hormonesneurohormonalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypatient populationpatients with breast cancerperson with breast cancerpilot studypreventpreventingprofessorreceptor mediated endocytosisresponserisk stratificationschool of medicinescreeningscreeningssocial rolestratify risktreat femalestreat womentreatment among femalestreatment among womentreatment in femalestreatment in womentrendwildtype mousewomen's treatment♀♂
Description preview
PROJECT SUMMARY
This project seeks to contribute new insights into the role of heme metabolism in the pathogenesis of
anthracycline cardiac toxicity by leveraging studies in human patients and mouse models. The project will be
led by Aarti Asnani, MD, Cardiologist and Director of Cardio-Oncology at Beth Israel Deaconess Medical
Center (BIDMC) and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click