🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Hematopoietic stem cell defects in Diamond-Blackfan Anemia
Organization ST. JUDE CHILDREN'S RESEARCH HOSPITALLocation MEMPHIS, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years oldAccelerationAddressAffectAllelic LossAllo BMTAllogeneic BMTAllogeneic Bone Marrow TransplantationAnemiaAnimal ModelAnimal Models and Related StudiesAntioncogene Protein p53AssayBioassayBiological AssayBiologyBloodBlood DiseasesBlood Precursor CellBlood Reticuloendothelial SystemBone MarrowBone Marrow GraftingBone Marrow Reticuloendothelial SystemBone Marrow TransplantBone Marrow TransplantationBone marrow failureCD34CD34 geneCITE sequencingCITE-seqCITEseqCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCUT&RUNCas nuclease technologyCell BodyCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCellular Tumor Antigen P53ChildChild YouthChildren (0-21)ChronicCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexDNA TherapyDNA mutationDataDefectDevelopmentDiamond-Blackfan anemiaDiseaseDisorderDysfunctionEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessErythrocyte TransfusionErythroidErythropoiesisExhibitsExperimental ModelsFailureFoundationsFunctional disorderFundingFutureGene ExpressionGene ProteinsGene TranscriptionGene Transfer ClinicalGenesGenetic ChangeGenetic InterventionGenetic TranscriptionGenetic defectGenetic mutationGlucocorticoidsGoalsHDM2HPCA1Hematologic DiseasesHematological DiseaseHematological DisorderHematopoiesisHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic stem cellsHeterograftHeterologous TransplantationHeterozygoteHumanImmune PrecipitationImmunoblottingImmunodeficient MouseImmunoprecipitationImpairmentIn VitroInherited bone marrow failureInvestigationLaboratoriesLoss of HeterozygosityMDM2MDM2 geneMDMX proteinMaintenanceMapsMarrow TransplantationMdm-2 proteinMediatingMentorshipMethodsModelingModern ManMolecularMutationMyelopoiesisNational Institutes of HealthOncoprotein MDM2Oncoprotein p53P53Pathway interactionsPatientsPhasePhenotypePhosphoprotein P53Phosphoprotein pp53PhysiciansPhysiologyPhysiopathologyPolycombPopulationPopulation HeterogeneityProcessProductionProtein DeficiencyProtein Gene ProductsProtein SubunitsProtein TP53RNA ExpressionRNA SeqRNA sequencingRNAseqRPS19RPS19 geneRed Blood Cell TransfusionRepressionRepressor ProteinsResearchRibo-seqRibonucleoproteinsRibosomal ProteinsRibosomal RNARibosomesScientistSpectroscopySpectrum AnalysesSpectrum AnalysisStructureTP53TP53 geneTRP53TestingTherapeuticTrainingTranscriptionTranslationsTransplantationTumor Protein p53Tumor Protein p53 GeneUbiquitin Ligase Component GeneUbiquitin Ligase GeneUnited States National Institutes of HealthWestern BlottingWestern ImmunoblottingXenograftXenograft procedureXenotransplantationallogeneic bone marrow transplantallogenic bone marrow transplantblood cell formationblood cell progenitorblood disorderblood formationblood progenitorblood stem cellblood-forming stem cellbone marrow allograftbone marrow failure syndromecareercareer developmentcellular indexing of transcriptomes and epitopes by single cell sequencingcofactorcytopeniadeficiency of proteindevelopmentaldiverse populationseffective therapyeffective treatmentelderly patientepigeneticallyerythroid developmentgene repair therapygene therapygene-based therapygenetic therapygenome mutationgenomic therapyglobal gene expressionglobal transcription profilehematopoietic differentiationhematopoietic hierarchyhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellheterogeneous populationheterozygosityhuman modelimprovedin vivoinfancyinfantileinherited disease of bone marrow failureinsightkidsloss of function mutationmdm-2 oncogene proteinmdm2 proteinmodel of animalmodel of humannew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approacholder patientp53 Antigenp53 Genesp53 Tumor Suppressorp53-Binding Protein MDM2pathophysiologypathwaypopulation diversityprogenitorprogenitor biologyprogenitor cell biologyprogenitor cell functionprogenitor cell maintenanceprogenitor functionprogenitor maintenanceprogramsprotein blottingprotein p53rRNArepressor complexribosome footprint profilingribosome profilingribosomopathyscRNA sequencingscRNA-seqself-renewself-renewalsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem and progenitor biologystem and progenitor cell functionstem and progenitor functionstem cell biologystem cell functionstem cell maintenancetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslationtranslatometransplanttransplant therapytransplant treatmenttransplantation therapytransplantation treatmentubiquitin ligasexeno-transplantxeno-transplantationyoungster
Applications closed.
Description preview
PROJECT SUMMARY
Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure disorder caused mainly by heterozygous
loss-of-function mutations in 20 out of 83 ribosomal protein (RP) genes, the most commonly affected one being
RPS19. DBA usually presents with erythroid production failure during infancy, although clinical observations…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click