grant

HEAL Research on Interventions for Stability and Engagement (RISE) Network Coordination Center

Organization RESEARCH TRIANGLE INSTITUTELocation RESEARCH TRIANGLE PARK, UNITED STATESPosted 30 Sept 2022Deadline 30 Jun 2027
NIHUS FederalResearch GrantFY2025AccelerationAccess to CareAddressAreaAssess implementationAwardClinical ResearchClinical StudyClinical TrialsCollaborationsCommon Data ElementCommunicationCommunitiesConsultationsDedicationsDevelopmentDrug usageDrug userDrugsEffectivenessEnvironmentEpidemiologyFeedbackFosteringHEAL InitiativeHarm MinimizationHarm ReductionHealth Services AccessibilityHelping End Addiction Long-termHelping to End Addiction Long-termImplementation assessmentImprove AccessIndividualInfrastructureInternationalInterventionInvestigatorsLeadershipLived experienceLived experiencesMeasuresMedicationMethodologyModelingMonitorMorbidityMorbidity - disease rateNational Institutes of HealthNeedle-Exchange ProgramsOpiatesOpioidOutcomeOverdosePWUDPharmaceutical PreparationsPoliciesPopulationPrincipal InvestigatorProcessProtocolProtocols documentationR-Series Research ProjectsR01 MechanismR01 ProgramRecommendationReportingResearchResearch DesignResearch GrantsResearch InfrastructureResearch MethodologyResearch MethodsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearch SupportResearchersResourcesRoleRunningServicesSiteStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStructureStudy TypeSyringe-Exchange ProgramsTranslatingTranslational ResearchTranslational ScienceTranslationsUnited StatesUnited States National Institutes of Healthaccess to health servicesaccess to servicesaccess to treatmentaccessibility to health servicesavailability of servicesbarriers to implementationcare accessclinical practicecommunity engagementconsultationdata diversitydata harmonizationdata infrastructuredata sharingdesigndesigningdevelopmentaldissemination strategydistribute naloxonediverse datadrug usedrug/agentengagement with communitiesepidemiologicepidemiologicalevaluate implementationevaluation of implementationevidence baseexperiencefacilitators to implementationfentanyl testharm reduction programsharmonized datahealth service accesshealth services availabilityhigh riskimplementation barriersimplementation challengesimplementation evaluationimplementation facilitatorsimplementation outcomesimplementation scienceimplementation strategyimprovedinfrastructure developmentinnovateinnovationinnovativeinterestinternet portalmortalitynaloxone availabilitynaloxone dispensarynaloxone dispensationnaloxone dispensingnaloxone distributionnaloxone provisionneedle exchangeon-line portalonline portaloperationoperationsoverdose deathoverdose educationoverdose fatalitiespeople who use drugspeople who use illicit drugspersons who use drugsprogramsprovide naloxoneresearch and methodsresearch studyresponseservice availabilityservice providerssocial rolestatistical analysisstrategies for implementationstudy designsubstance usesubstance usingsuccesssupport networksyringe exchangesyringe exchange servicessyringe service programssyringe servicessystematic reviewtest for fentanyltest striptheoriestranslationtranslation researchtranslational investigationtreatment accessuser centered designweb portalweb-based portal
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Full Description

The magnitude of the overdose crisis has led to an increased focus on improving access to services to mitigate the negative consequences associated with the use of opioids and other substances. The National Institutes of Health (NIH), through the Helping to End Addiction Long-term (HEAL) Initiative, has launched a collective of nine research projects and a Coordination Center (CC) to improve understanding of the effectiveness and outcomes of implementation of community-based programs and services for people who use drugs. RTI International proposes to serve as the CC for the HEAL Research on Interventions for Stability and Engagement (RISE) Network. In this capacity, RTI will establish a centralized structure for scientific, administrative, and logistical operations that facilitates network coordination and communication (Aim 1).

RTI will facilitate a network-engaged process of developing common metrics and measures to support HEAL data harmonization, data infrastructure and sharing, and provide methodology consultations (Aim 2). RTI will establish an infrastructure that facilitates meaningful engagement of interested parties representing individuals and communities at highest risk for the negative consequences associated with drug use (Aim 3). To accelerate the translation of research findings into practice, RTI will establish a research infrastructure that facilitates the timely development and dissemination of translational products, including effective dissemination strategies through user-centered design (Aim 4). Our team of core leaders, co-investigators, and scientific advisors are experts in data harmonization, statistical methodology, data infrastructure development and management, and implementation science.

RTI has extensive experience successfully running CCs across NIH and retains substantive collective expertise in substance use research and community engagement to implement a portfolio of scientific and support activities for the network. The RISE-CC will provide the needed robust central operation to coordinate a comprehensive multi-project, multi-pronged research endeavor.

Grant Number: 5U24DA057611-04
NIH Institute/Center: NIH

Principal Investigator: Jessica Cance

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HEAL Research on Interventions for Stability and Engagement (RISE) Network Coordination Center — RESEARCH TRIANGLE INSTI | Dev Procure