grant

HD2A RASC - Pain Implementation Support Core

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 30 Sept 2022Deadline 31 Aug 2027
NIHUS FederalResearch GrantFY2025AcademyAccelerationAccidentsAcuteAddressAdoptionAdverse effectsAdvocacyAmericanAttentionBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentCaringCatalogsCell Communication and SignalingCell SignalingCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Cessation of lifeChargeCommon Data ElementComplexConditioning TherapyData AnalyticsDeathDevelopmentDiagnosisDimensionsDrug TherapyEducationEducational aspectsEpidemicEvidence based practice guidelinesFundingGoalsGuidelinesHealth Care SystemsHealth StatusImpairmentInstitute of MedicineInstitute of Medicine (U.S.)InterventionIntracellular Communication and SignalingInvestigatorsLeadLearningLevel of HealthLinkLong-Term EffectsManaged CareMeasuresMediationMedicineMethodologyMethodsModelingMorbidityMorbidity - disease rateMotivationNAS/IOMNational Institutes of HealthNegotiatingNegotiationOpiatesOpioidOverdosePainPain CentersPain ClinicsPain ControlPain Relief UnitsPain TherapyPain managementPain qualityPainfulPatientsPb elementPharmacological TreatmentPharmacotherapyPhasePoliciesPrevalencePreventionPublic HealthPublicationsQOCQOLQualifyingQuality of CareQuality of lifeRecommendationRecovery SupportReportingResearchResearch PersonnelResearchersRisk FactorsScienceScientific PublicationScientistSignal TransductionSignal Transduction SystemsSignalingTimeTranslatingUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionUnited States National Institutes of Healthbehavior interventionbehavioral interventionbiological signal transductioncareercatalogchronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentconferenceconventiondevelopmentaldisabilitydrug interventiondrug treatmentevidence baseevidence based guidelinesevidence based recommendationshealth levelheavy metal Pbheavy metal leadhigh riskimplementation facilitationimplementation interventionimplementation measuresimplementation outcomesimplementation scienceimplementation strategyimplementation trialimprovedinformation gatheringinnovateinnovationinnovativelicit opioidlife spanlifespanmedication for opioid use disordermembernon-medical use of prescription opiatesnon-medical use of prescription opioidsnonmedical use of prescription opiatesnonmedical use of prescription opioidsopiate crisisopiate medicationopiate overdoseopiate related overdoseopiate therapyopiate use disorderopioid analgesic misuseopioid crisisopioid drug overdoseopioid epidemicopioid induced overdoseopioid intoxicationopioid medicationopioid medication misuseopioid medication overdoseopioid overdoseopioid poisoningopioid prescription medication misuseopioid related overdoseopioid therapyopioid toxicityopioid use disorderoverdose deathoverdose fatalitiespain interventionpain reliefpain treatmentpatient centeredpatient orientedperson centeredpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspopulation healthpractical implementationpragmatic implementationprescribed opiateprescribed opioidprescription opiateprescription opiate misuseprescription opioidprescription opioid misuseprimary care providerproviders from primary careproviders of primary carerelieve painresource guidesshared decision makingskillsstemstrategies for implementationsummitsymposiasymposiumtreat chronic paintreatment guidelinesuptake
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Full Description

PAIN IMPLEMENTATION SUPPORT CORE: PROJECT SUMMARY/ABSTRACT
The ongoing opioid overdose crisis – the leading cause of accidental deaths among Americans – has at its roots inadequately treated opioid use disorder (OUD) and pain. This reality has been recognized by the National Academy of Medicine and the Centers for Disease Control and Prevention, among other major organizations charged with protecting the public health, sparking an unprecedented influx of funding and policy changes to stem the tide of overdose deaths. The nationwide attention and funding increase have driven a marked rise in the development of evidence-based, high-quality pain treatments and treatment guidelines addressing the full spectrum of public health need: from prevention to person-centered care to treatment to recovery support. However, there has been woefully inadequate uptake of these treatments in real-world practice. For example, primary care providers--the most frequent prescribers of long-term opioid therapy for pain--often lack skills and/or time to fully implement evidence-based guidelines, putting already vulnerable patients at even higher risk for opioid-related harms, especially overdose, and poorly-controlled chronic pain. Effectively translating research findings into practice and ameliorating these real-world quality of care deficits are the domains of implementation science (IS). As a key RASC core, the overarching goal of the Pain Implementation Support (Pain-IS) Core is to support HD2A Innovation/Acceleration Projects in successful implementation of effective pain interventions through the coordinated efforts of a highly expert collaborative team, deploying and advancing cutting edge IS methods. We will bring the best of IS to the pain treatment quality gap, unifying implementation scientists and pain researchers—with the proximal goal of enhancing research in the Innovation/Acceleration Projects and the ultimate goal of impacting the public health. Specifically, in alignment with the other Cores, we will ASSESS the current status of key components of the Innovation/Acceleration Projects on IS capability in 5 key dimensions: a) evidentiary basis for the intervention; b) stakeholder engagement c) contextual determinants; d) selection of implementation strategies; and, e) implementation outcomes. We will ASSIST the Innovation/Acceleration Projects using the information gathered in the ASSESS phase in order to: a) enhance motivation to enhance their studies with tailored IS approaches that draw upon the Core’s expertise; b) provide an Implementation Support Plan on the components above and using a shared decision-making approach to determine how best to offer technical assistance (implementation support); and, c) to co-lead the RASC Learning Collaborative. In concert with the RASC and other cores, we will ADVANCE the Innovation/Acceleration projects’ activities with respect to sustainment: linking projects with the field at large, promoting projects’ impacts on policy/financing, and facilitating ongoing stakeholder engagement towards advocacy.

Grant Number: 5U2CDA057717-04
NIH Institute/Center: NIH

Principal Investigator: WILLIAM BECKER

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