grant
HBV cccDNA transcriptional silencing with and without HIV
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 22 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AIDS VirusATAC sequencingATAC-seqATACseqAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffectAnti-Retroviral AgentsAssayAssay for Transposase-Accessible Chromatin using sequencingBindingBioassayBiological AssayBlood PlasmaBlood SerumBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCandidate Disease GeneCandidate GeneCas nuclease technologyCause of DeathCell BodyCell CountCell NumberCellsCessation of lifeChIP assayCharacteristicsChromatinChronicChronic Hepatitis BCircular DNAClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-ImmunoprecipitationsComplementary DNACytoplasmDataDeathDisease OutcomeEC 2.1.1EpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessGene InactivationGene SilencingGene TranscriptionGenesGenetic TranscriptionGoalsHBVHBV cureHBV diseaseHBV functional cureHBV infected individualsHBV infection in patientsHBV infection in peopleHBV patientsHBV therapeuticHBV therapyHBV treatmentHDAC AgentHDAC inhibitorHIVHIV and HBVHIV and hepatitis BHIV-HBVHIV/HBVHIV/hepatitis BHIV/hepatitis B virusHep G2HepBHepG2HepG2 cell lineHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatitisHepatitis BHepatitis B TherapeuticHepatitis B TherapyHepatitis B TreatmentHepatitis B VirusHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHistone Deacetylase InhibitorHistone deacetylase inhibitionHistonesHumanHuman Immunodeficiency VirusesImmune Cell ActivationIn VitroIndividualInfectionInterruptionKnock-outKnockoutKnowledgeLAV-HTLV-IIILiverLiver CellsLiver Cells CarcinomaLiver diseasesLymphadenopathy-Associated VirusMeasurableMeasuresMessenger RNAMethodsMethylationMethyltransferaseModelingModern ManModificationMolecularMolecular InteractionNon-Polyadenylated RNAPathway interactionsPersonsPlasmaPlasma SerumPrimary carcinoma of the liver cellsProcessRNARNA ExpressionRNA Gene ProductsRNA SeqRNA SplicingRNA sequencingRNAseqResolutionReticuloendothelial System, Serum, PlasmaReverse TranscriptionReverse Transcription InhibitionRibonucleic AcidSamplingSerumSplicingT-Cell DepletionT-cell depletion therapyT-lymphocyte depletion therapyT4 CellsT4 LymphocytesTestingTissuesTranscriptTranscriptionTransferaseTransferase GeneUse of New TechniquesVariantVariationViralViral Gene ProductsViral Gene ProteinsViral Hepatitis BViral ProteinsViral hepatitisVirionVirus ParticleVirus ReplicationVirus-HIVanaloganti-retroviralassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcDNAcDNA Librarychromatin immunoprecipitationchronic HBV infectionchronic hepatitis B infectionchronic hepatitis B virus infectionchronic infections with hepatitis B viruschronically infected with HBVchronically infected with hepatitis Bcircular RNAclosed circular RNAco-infectioncoinfectionddPCRdevelop therapydifferential expressiondifferentially expresseddroplet digital PCRdroplet digital Polymerase Chain Reactiondroplet-based digital PCRend stage liver diseaseend stage liver failureepigeneticallyglobal gene expressionglobal transcription profilehep Bhepatic body systemhepatic diseasehepatic organ systemhepatitis B curehepatitis B functional curehepatitis B patientshepatitis B virus and human immunodeficiency virushepatitis B virus curehepatitis B virus diseasehepatitis B virus functional curehepatitis B virus infected individualshepatitis B virus infection in patientshepatitis B virus infection in peoplehepatitis virus infectionhepatopathyhistone modificationimmune activationin vitro testingindexingindividuals with HBVindividuals with hepatitis Binterestintervention developmentintrahepaticlaser capture microdissectionliver carcinomaliver disordermRNAmethylasemultidisciplinarynano porenanoporenoveloverexpressoverexpressionpathwaypatients with HBVpatients with hepatitis Bpeople with HBVpeople with hepatitis Bresolutionsspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstherapy developmenttooltranscriptional differencestranscriptional silencingtranscriptometranscriptome sequencingtranscriptomic sequencingtransmethylasetreatment developmentviral DNAviral RNAviral multiplicationviral reboundviral replicationvirus DNAvirus RNAvirus multiplicationvirus proteinvirus rebound
Description preview
Hepatitis B virus (HBV) infects >300 million people chronically and is the leading cause of end-stage liver
disease and hepatocellular carcinoma (HCC), resulting in ~1 million deaths annually. HIV is a common co-
infection in people with chronic hepatitis B (CHB) and worsens HBV and liver disease outcomes. Liver disease
is a leading cause of death…
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