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Harnessing the anti-inflammatory activity of extracellular sialylation of IgG.
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 16 Apr 2021Deadline 31 Mar 2026 โ ๏ธ
NIHUS FederalResearch GrantFY20257S Gamma GlobulinAffinityAllergyAmino Acid SequenceAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesAntibody TherapyAntigen-Antibody ComplexAssayAtrophic ArthritisAttenuatedAutoantibodiesAutoimmuneAutoimmune DiseasesB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBioassayBiologicalBiological AssayBiologyBiophysicsBlood PlasmaBlood PlateletsCD209CD209 geneCDSIGNCancersCell LineageClinicalClinical TrialsCommunicable DiseasesD-GalactoseDC-SIGNDC-SIGN1DataDepositDepositionDevelopmentDiseaseDisorderDissectionDoseEC 2.4EngineeringEnzyme GeneEnzymesExhibitsFc-Gamma Receptor IIGalactopyranoseGalactopyranosideGalactoseGlycansGlycoside TransferasesGoalsHepatic CellsHepatic Parenchymal CellHepatocyteHospitalsIGIVIV ImmunoglobulinsIVIGIgGIgG ReceptorsIgG1IgG2IgG3IgG4Immune ComplexImmune globulin IVImmune responseImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunoglobulin GImmunoglobulin G ReceptorImmunologyImmunosuppressed HostIn SituIn VitroIndividualInfectious DiseasesInfectious DisorderInflammationInflammatoryInstitutionIntravenous AntibodiesIntravenous IGIntravenous Immune GlobulinIntravenous ImmunoglobulinsKidneyKidney Urinary SystemKnowledgeLiver CellsLupus Erythematosus DisseminatusMalignant NeoplasmsMalignant TumorMarrow plateletMediatingMetabolic GlycosylationMiceMice MammalsMissionModelingMolecularMolecular InteractionMurineMusN-Acetylneuraminic AcidsNational Institutes of HealthNecrotizing Respiratory GranulomatosisNephritisNephrotoxicOutcomePathogenicityPathway interactionsPatientsPlasmaPlasma SerumPlateletsPoliciesPolysaccharidesPreparationPrimary Protein StructurePropertyPublic HealthRecombinant Immune GlobulinRegulationReplacement TherapyResearchReticuloendothelial System, Serum, PlasmaRheumatoid ArthritisRoleSLESialic AcidsSiteSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTestingTherapeuticTherapeutic Immune GlobulinTherapeutic ImmunoglobulinTherapeutic UsesThrombocytesThrombocytopeniaThrombopeniaTransplantationUnited States National Institutes of HealthWegener's Granulomatosisantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentattenuateattenuatesattenuationautoimmune antibodyautoimmune arthritisautoimmune conditionautoimmune disorderautoimmune inflammationautoimmune reactivityautoimmunity diseaseautoreactive antibodyautoreactivitybiologicbiophysical foundationbiophysical principlesbiophysical sciencesdesigndesigningdevelopmentaldisseminated lupus erythematosusexperimentexperimental researchexperimental studyexperimentsextracellulargamma Fc Receptorsglycosylated IgGglycosylated immunoglobulin Gglycosylationglycosyltransferasegranulomatosis with polyangiitishost responseimmune system responseimmunoresponseimmunosuppressed patientimprovedin vivoinnovateinnovationinnovativeinsightkidney toxicitymalignancymouse modelmurine modelneoplasm/cancernephrotoxicitynovelpathwaypreparationsprotein sequencereceptor bindingreceptor boundrenalrheumatic arthritisself reactive antibodysialylationsocial rolesuccesssugar nucleotidesystemic lupus erythematosistransplant
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Project Summary/Abstract.
Despite the tremendous clinical success of immunotheraputics, little is known regarding IgG2-4 biology relative
to IgG1. Our long-term goal is to understand how glycosylation of antibodies regulates, and is regulated, by
immune responses. The overall objective of this application is to examine the regulation ofโฆ
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