grant
Harnessing lysosome trafficking for enhanced antigen presentation
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 20 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAdjuvantAntibodiesAntibody ResponseAntigen PresentationAntigen TargetingAntigensAssayAutoimmune StatusAutoimmunityB7-H1Binding Site DomainBioassayBiological AgentBiological AssayBiological ProductsBiomedical EngineeringCD274CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD71CancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell Surface ProteinsCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyClinicalCommunicable DiseasesComplexDataDendritic CellsDevelopmentDigestionDiseaseDisease OutcomeDisorderEGF ReceptorEGFRERBB ProteinEngineeringEnzyme GeneEnzymesEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsFoundationsFutureGeneticGenetic DiseasesGoalsHER1Histocompatibility ComplexHistocompatibility ComplicesHumanIGF Type 2 ReceptorIGF-2IGF-2 ReceptorIGF-IIIGF-II ReceptorImmuneImmune responseImmunesImmunityImmunochemical ImmunologicImmunofluorescenceImmunofluorescence ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyIndividualInfectionInfectious DiseasesInfectious DisorderInnate ImmunityInsulin-Like Growth Factor 2Insulin-Like Growth Factor IIInsulin-Like Growth Factor II ReceptorInsulin-Like Growth Factor Type 2 ReceptorInsulin-Like Somatomedin Peptide IIIntracellular Communication and SignalingL monocytogenesL. monocytogenesLibrariesLigand Binding DomainLigandsListeria monocytogenesLysosomesM tbM tuberculosisM. tbM. tuberculosisMHC ReceptorMajor Histocompatibility ComplexMajor Histocompatibility Complex ReceptorMajor Histocompatibility ComplicesMalignant NeoplasmsMalignant TumorMannose-6-Phosphate ReceptorMeasuresMediatingMetabolic Protein DegradationModern ManMultiplication-Stimulating ActivityMultiplication-Stimulating FactorMycobacterium tuberculosisNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNucleic AcidsOncologyOncology CancerOutcomePD-L1PDL-1Pathway interactionsPeptide Signal SequencesPeptidesPhosphoproteinsPopulationProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1Protein EngineeringProtein Replacement TherapyProtein TraffickingProtein TurnoverProteinsReceptor ProteinRecombinantsRegulatory Protein DegradationReporterRoleSignal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingSiteSomatomedin ASomatomedin MSASubcellular ProcessSystemT cell responseT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT4 CellsT4 LymphocytesTFR geneTFR proteinTFR1TFRCTFRC geneTGF-alpha ReceptorTRFRTechnologyTestingTransferrin ReceptorTransferrin Receptor 1Transforming Growth Factor alpha ReceptorUrogastrone ReceptorVaccinesVeiled CellsWorkantigen-specific T cellsbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbiologicsbiopharmaceuticalbiotherapeutic agentc-erbB-1c-erbB-1 Proteincell biologycytokinecytotoxicdesigndesigningdevelopmentaldisease controldisease modeldisorder controldisorder modelengineered T cellsengineered immune systemenzyme replacement therapyenzyme replacement treatmenterbB-1erbB-1 Proto-Oncogene ProteinerbBlgenetic conditiongenetic disordergenetic protein engineeringgenetically engineered T-cellshost responsehuman diseaseimmune engineeringimmune system responseimmunoengineeringimmunogenimmunoresponsemalignancymannose 6 phosphatemicrobial antigenmicroorganism antigenmtbneoplasm/cancernovelpathogenpathwayprogrammed cell death ligand 1programmed cell death protein ligand 1protein death-ligand 1protein degradationprotein designprotein signal sequenceprotein transportproto-oncogene protein c-erbB-1prototypereceptorreceptor bindingreceptor boundrepurposingsocial rolethymus derived lymphocytetraffickingtransgenic T- cellstranslational opportunitiestranslational potentialtumoruptake
Description preview
Project Summary
Robust antigen-specific CD4⁺ T cell responses are critical for effective immunity against cancer
and infection. Despite advances in adjuvant development and cytokine modulation, strategies to
optimize antigen delivery for MHC-II presentation remain underdeveloped. This proposal
introduces a modular platform for antigen…
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