🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Harnessing engineered T regulatory cells to promote beta cell health in T1D
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 8 Apr 2022Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAddressAdultAdult HumanAffectAntigen PresentationAntigensAutoimmune DiseasesAutoimmune ResponsesAutoimmune StatusAutoimmunityB9 endocrine pancreasBeta CellBrittle Diabetes MellitusCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8BCD8B1CD8B1 geneCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell ProtectionCell SignalingCell SurvivalCell ViabilityCellsCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular injuryChildChild YouthChildren (0-21)ClinicalCytoprotectionDiseaseDisorderDysfunctionER stressElementsEndocrine PancreasEngineered GeneEngineeringEnvironmentFOXP3FOXP3 geneForkhead Box P3Functional disorderGenesGoalsHealthHomeHomingHumanHumulin RHyperglycemiaIDDMImmune TargetingImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInflammationInflammatoryInsulinInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusInterventionIntracellular Communication and SignalingInvestigatorsIslands of LangerhansIslets of LangerhansJM2Juvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLYT3MHC ReceptorMajor Histocompatibility Complex ReceptorMeasuresMediatingModern ManNesidioblastsNovolin ROrganPancreasPancreaticPancreatic IsletsPars endocrina pancreatisPhysiopathologyPreventionRecoveryRegular InsulinRegulatory T-LymphocyteResearch PersonnelResearchersRiskSCURFINSignal TransductionSignal Transduction SystemsSignalingSiteSpecificityStressSubcellular ProcessSudden-Onset Diabetes MellitusSuppressor CellsSuppressor-Effector T-CellsSuppressor-Effector T-LymphocytesT Suppressor CellT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMT4 CellsT4 LymphocytesTeff cellTestingTherapeuticTimeTregType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusWorkactivate T cellsadulthoodantigen based testantigen testautoimmune attackautoimmune conditionautoimmune destructionautoimmune disorderautoimmune pathogenesisautoimmunity diseasebiological adaptation to stressbiological signal transductioncell damagecell growthcell injurycell stresscellular damageconstitutive expressionconstitutive gene expressioncytoprotectivedamage to cellsdeamidationdesigndesigningdraining lymph nodeeffector T cellendoplasmic reticulum stressengineered T cellsengineered immune systemgenetically engineered T-cellshomeshyperglycemicimmune engineeringimmune suppressionimmune suppressive activityimmune suppressive functionimmunoengineeringimmunogenimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinjury to cellsinjury to tissueinsulin dependent diabetesinsulin dependent type 1isletislet autoantibodyislet cell antibodyjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidsknowledge integrationlentiviral-transducedlentivirally transducedlentivirus transducedmouse modelmurine modelnative protein drugneo-antigenneo-epitopesneoantigensneoepitopesnovelpathophysiologyperipheral bloodpharmaceutical proteinprotein drug agentprotein-based drugreaction; crisisregional lymph noderegulatory T-cellsrepairrepairedsite targeted deliverystress responsestress; reactionsuppressor T lymphocytetargeted deliverytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic proteinthymus derived lymphocytetissue injurytissue repairtransgenic T- cellstype I diabetestype one diabetesyoungsterβ-cellβ-cellsβCell
Applications closed.
Description preview
Summary
Type 1 diabetes (T1D) is characterized by the destruction of β-cells, driven through autoimmune attack directed
at the pancreatic islet. In concert with β-cell destruction, β-cell stress and injury contribute to disease by initiating
enzymatic activities that compromise β-cell function and generate neoantigens. The investigators of this…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click