grant
Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging
Organization COLD SPRING HARBOR LABORATORYLocation COLD SPRING HARBOR, UNITED STATESPosted 15 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ASCVDAdult-Onset Diabetes MellitusAffectAge related pathologiesAgingAilmentary SystemAlimentary SystemAntigensAtherosclerosisAtherosclerotic Cardiovascular DiseaseBiologyBiology of AgingBody TissuesBreedingCAR T cellsCAR modified T cellsCAR-TCAR-TsCategoriesCell AgingCell BodyCell SenescenceCell TherapyCell to Cell Communication and SignalingCell-Cell SignalingCellsCellular AgingCellular SenescenceChemicalsComplexConsumptionDasatinibDataDevelopmentDigestive SystemDoseEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessGastrointestinal Body SystemGastrointestinal Organ SystemGenome InstabilityGenomic InstabilityGoalsIndividualKetosis-Resistant Diabetes MellitusLightMaturity-Onset Diabetes MellitusMiceMice MammalsMitochondriaModelingMurineMusNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusPhenotypePhotoradiationPhysiologicPhysiologicalProcessReplicative SenescenceResearchResearch ResourcesResourcesSafetySlow-Onset Diabetes MellitusSpecificityStable Diabetes MellitusSurfaceT cells for CART2 DMT2DT2DMTechnologyTelomere ShorteningTherapeuticTherapeutic StudiesTherapy ResearchTimeTissuesToxic effectToxicitiesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUse EffectivenessWorkaberrant agingabnormal agingabnormal protein homeostasisabnormal proteostasisaccelerated agingaccelerated biological ageaccelerated biological agingadult onset diabetesage accelerationage associated diseaseage associated disorderage associated impairmentage associated pathologiesage dependent diseaseage dependent disorderage dependent impairmentage dependent pathologiesage induced pathologiesage related human diseaseage-related diseaseage-related disorderage-related impairmentaged miceaged mouseaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging pathologiesaging processaging related pathologiesantagonismantagonistatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasecell based interventioncell engineeringcell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular engineeringcellular therapeuticcellular therapychimeric antigen T cell receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellscostdefective nutrient sensingdefective proteostasisdeficient nutrient sensingderegulated nutrient-sensingderegulation of nutrient sensingdesigndesigningdetection of nutrientdevelopmentaldysfunctional age related changedysfunctional agingdysregulated nutrient sensingeffectiveness usingelderly miceepigeneticallyexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblegastrointestinal systemhallmarks of aginghealthspanhealthy life spanimmunogenimpaired agingimpaired nutrient sensingimprovedinsightintercellular communicationirradiationketosis resistant diabeteslife spanlifespanmaladaptive agingmaturity onset diabetesmitochondrialmitochondrial dysfunctionmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynutrient sensingold micepathological age related changespathological agingperception of nutrientspillars of agingprogramsprotein homeostasis declineprotein homeostasis deficiencyprotein homeostasis dysfunctionprotein homeostasis failureprotein homeostasis lossproteostasis declineproteostasis defectproteostasis deficiencyproteostasis dysfunctionproteostasis dysregulationproteostasis failureproteostasis impairmentproteostasis lossreplicative agingresponsesenescencesenescentsenescent cellsenolyticssmall moleculespatial and temporalspatial temporalspatiotemporalstem cell depletionstem cell exhaustionstem cell fatiguetelomere attritiontherapeutic evaluationtherapeutic testingtooltype 2 DMtype II DMtype two diabetes
Description preview
SUMMARY
To date nine hallmarks of the aging process have been described, which can be grouped into three major
categories: primary hallmarks or cause of damage (genomic instability, telomere attrition, epigenetic alterations
and loss of proteostasis), antagonist hallmarks or responses to damage (cellular senescence, mitochondrial
dysfunction and…
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