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H3 histone oxidation is a new posttranslational modification linking heavy metal-induced metabolic changes and oncegenic epigenetic reprogramming
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 23 Jan 2024Deadline 30 May 2025 β οΈ
NIHUS FederalResearch GrantFY2025AbscissionActive OxygenAffectAmino AcidsAntioxidantsAreaArsenicAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBindingBiologicalBone-Derived Transforming Growth FactorBreast CancerBreast Cancer CellBreast Cancer PatientBreast MetastasisBreast NeoplasmsBreast Tumor PatientBreast TumorsCadmiumCd elementCell BodyCell NucleusCell ReprogrammingCellsChemoresistanceChromatinClinicalCommunitiesCysteineDataDevelopmentDiseaseDisease ProgressionDisorderDoseER PositiveER+Environmental HealthEnvironmental Health ScienceEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumEstrogen receptor positiveExcisionExposure toExtirpationFDA approvedGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGenomicsH2O2Half-CystineHealth InequityHeavy MetalsHeterochromatinHistone H3HistonesHydrogen PeroxideHydroperoxideInequalities in HealthInequities in HealthIntermediary MetabolismInternationalInterruptionInterventionL-CysteineL-SerineLeadLicensingLinkLiquid substanceLow Income PopulationLow incomeLow income groupMalignant Breast NeoplasmMalignant CellMammary CancerMammary NeoplasmsMesenchymalMetabolicMetabolic ProcessesMetabolismMetal exposureMetalsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMetastatic breast cancerMetastatic/RecurrentMiceMice MammalsMilk Growth FactorMitochondriaMolecular InteractionMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMurineMusNeoplasm MetastasisNuclearNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNucleosomesNucleusOrganoidsOxidation-ReductionOxidative StressOxygen RadicalsPathway interactionsPatientsPb elementPhenotypePlatelet Transforming Growth FactorPlayPollutionPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary NeoplasmPrimary TumorPro-OxidantsProcessProductionProtective AgentsProtective DrugsProtein ModificationRNA ExpressionReactive Oxygen SpeciesRecommendationRedoxRegulationRegulatory RegionsRemovalResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugRoleSERMsSecondary NeoplasmSecondary TumorSelective Estrogen Receptor ModulatorsSerineStem Cell likeSurgical RemovalTGF BTGF-betaTGF-Ξ²TGFbetaTGFΞ²TamoxifenTestingTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTreatment EfficacyTumor CellVariantVariationWorld Health OrganizationXenograft Modelacquired drug resistanceaminoacidarsenicsbiologicbreast cancer metastasisbreast cancer progressionbreast tumor cellcancer cellcancer cell metabolismcancer drug resistancecancer metabolismcancer metastasiscancer progressioncatalasecellular reprogrammingchemoresistantchemotherapychemotherapy resistancechemotherapy resistantchromatin remodelingcostcytokinedevelopmentaldisparities in morbiditydrivingenvironmental health disparityepigeneticallyepithelial to mesenchymal transitionexposure to metalfluidgenetic regulatory elementhealth inequalitiesheavy metal Pbheavy metal leadimprovedin vivoindividuals with breast cancerintervention efficacyliquidlow income individuallow income peoplemalignant breast tumormammary tumormetastatic breast tumormetastatic mammary cancermetastatic mammary tumormimeticsmitochondrialmorbidity disparitiesmortalitymulti-drug resistantmultidrug resistantmutantneoplasm progressionneoplastic cellneoplastic progressionnoveloxidationoxidation reduction reactionpathwaypatients with breast cancerperson with breast cancerpharmacologicpollutantpreventpreventingprogenitor capacityprogenitor cell likeprogenitor-likeprogramsresectionresistance to cancer drugsresistance to therapyresistantresistant to cancer drugsresistant to therapysocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicsstem cell characteristicsstem-likestemnesstherapeutic efficacytherapeutic outcometherapeutic resistancetherapy efficacytherapy outcometherapy resistanttranscription factortreatment resistancetumor cell metabolismtumor cell metastasistumor metabolismtumor progressiontumor xenograftxenograft transplant modelxenotransplant model
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Description preview
SUMMARY
Transcription stability enforces cellular identity and is tightly controlled by restrictions imposed on
both transcription factor function and target gene accessibility. Progression of cancer to
metastasis and multi-drug resistance requires fluid transcriptional programs that can explore
different genomic landscapes to enable clonalβ¦
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