grant
Gut microbiome manipulation to improve efficacy and durability of anti-TNF treatments for inflammatory bowel disease
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 1 May 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026(TNF)-α12-20 years oldAb responseAbdominal PainAbscissionAddressAdolescenceAffectAfter CareAfter-TreatmentAftercareAmericanAnemiaAnti-Tumor Necrosis Factor TherapyAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAntibodiesAntibody FormationAntibody ProductionBody TissuesC57BL/6 MouseCSIFCSIF-10CachectinCaringChronic DiseaseChronic IllnessClinicalClinical DataClinical ManagementCluster AnalysesCluster AnalysisCoupledCytokine Synthesis Inhibitory FactorDataDevelopmentDiagnosisDiarrheaDisease ManagementDisease OutcomeDisease remissionDisorder ManagementDrugsEffectivenessExcisionExposure toExtirpationFDA approvedFecesFunctional MetagenomicsFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGene ClusterGerm-FreeHeterogeneityHumanHuman MicrobiomeIL-10IL10IL10AIP injectionImmune mediated therapyImmunologically Directed TherapyImmunotherapyInduction TherapyInflammatory Bowel DiseasesInflammatory Bowel DisorderIngestionInjectionsInterleukin 10 PrecursorInterleukin-10Intestinal DiseasesIntestinal DisorderIntraperitoneal InjectionsKnock-outKnockoutLabelLiteratureMacrophage-Derived TNFMediatingMedicationMelanoma patientMetagenomicsMiceMice MammalsMicrobeMiscellaneous AntibioticModelingModern ManMolecularMonocyte-Derived TNFMurineMusNEOADJNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentOncologyOncology CancerOperative ProceduresOperative Surgical ProceduresPD-1 antibodyPD1 antibodyPatientsPharmaceutical PreparationsPreclinical dataProductivityQOLQuality of lifeRefractoryRemissionRemovalResearchResortRiskRoleSamplingShapesSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-cell therapeuticsT-cell transfer therapyTNFTNF ATNF AlphaTNF geneTNF therapyTNF-αTNFATNFαTestingTherapeuticTimeTissuesTransplant RecipientsTransplantationTreatment EfficacyTreatment FactorTreatment FailureTumor Necrosis FactorTumor Necrosis Factor TherapyTumor Necrosis Factor-alphaaPD-1aPD1adolescence (12-20)adoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyanti programmed cell death 1anti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 monoclonal antibodiesanti-TNF therapyanti-TNF-alpha therapyanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyantiPD-1antibody biosynthesisbacterial disease treatmentbacterial infectious disease treatmentbiobankbiorepositorybowel inflammationchronic disorderclinical efficacycommunity microbescost effectivedebilitating symptomdevelopmentaldigestive tract microbiomedrug/agentearly adulthoodeffective therapyeffective treatmentemerging adultenteric microbial communityenteric microbiomeenteric microbiotaexhaustfecal microbial transplantationfecal microbiomefecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal samplefecal transplantfecal transplantationgastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehuman-associated microbiomeimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoglobulin biosynthesisimprovedinduction therapiesinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineingestinhibitorintervention efficacyintestinal autoinflammationintestinal biomeintestinal floraintestinal inflammationintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine diseaseintestine disorderknowledge of resultsmetabolism measurementmetabolomicsmetabonomicsmicrobe communitymicrobial communitymicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremicrobiota compositionmicroorganism communitymouse modelmurine modelpatient responsepatient specific responsepatients suffering from melanomapatients with melanomapolymicrobial communitypost treatmentpre-clinicalpreclinicalpreclinical findingspreclinical informationpreventpreventingprophylacticresectionresponseresponse to therapyresponse to treatmentresponsive patientsmall moleculesocial rolestoolstool microbiomestool samplestool specimenstool-associated microbiomesurgerytherapeutic T-cell platformtherapeutic efficacytherapeutic responsetherapy efficacytherapy failuretherapy responderstherapy responsetranscriptomicstransplanttransplant patienttreatment effecttreatment responderstreatment responsetreatment responsivenessαPD-1αPD1
Description preview
Project Summary/Abstract:
This proposal addresses the significant challenge of limited treatment options in inflammatory bowel disease
(IBD) and the loss of response to therapies that were previously effective. The long-term objective is to
improve the clinical management of IBD by enhancing the initial response to therapy and extending the…
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