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Gut barrier function in Alzheimer’s disease
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Feb 2021Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY202527E10 Antigen4-O-beta-D-galactopyranosyl-D-fructoseA β-42A β42A-beta 42A-beta42AD dementiaAD modelAD pathologyAD related dementiaADRDAbeta-42Abeta42AccelerationAddressAgeAgingAlimentary CanalAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmyloidAmyloid SubstanceAmyloid beta-42Amyloid beta42Amyloid β-42Amyloid β42Amyloidβ-42Amyloidβ42Antibody titer measurementAssayAutomobile DrivingAutoregulationAβ-42Aβ42BBB permeabilizationBBB permeableBioassayBiological AssayBiological MarkersBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain Nervous SystemCalcium-Binding Myeloid Protein P8,14CalgranulinCalprotectinCell Communication and SignalingCell SignalingCephulacCerebrospinal FluidChemicalsChronulacCirculationClinicalCognitiveCollectionD-MannitolDegenerative Neurologic DisordersDerivationDerivation procedureDevelopmentDigestive TractDiseaseDisease ProgressionDisorderEncephalonFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2GI TractGI microbiomeGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGerm-FreeGnotobioticGnotobioticsGoalsGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHemato-Encephalic BarrierHomeostasisHumanImmune responseImmune systemImpairmentIndividualInfrastructureInnate Immune ResponseIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityIntestinesIntracellular Communication and SignalingL1 AntigenLactuloseLeukocyte L1 Antigen ComplexLeukocyte L1 ProteinLinkLipopolysaccharidesLiquid substanceMT-bound tauMannitolMeasuresMechanistic Target of RapamycinMediatingMethodsMiceMice MammalsMicrobeMicrobiologyMigratory Inhibitory Factor-Related Protein MRPModern ManMucous body substanceMucusMurineMusMyelomonocytic Antigen L1Nerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationOsmitrolPETPET ScanPET imagingPETSCANPETTParticipantPathogenesisPathologyPermeabilityPersonsPhysiological HomeostasisPlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessPublishingRAFT1Rad.-PETReportingResearchResearch ResourcesResectisolResourcesRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSodium Dextran SulfateSystemTestingTherapeuticTimeUnited StatesWisconsinWorkage associatedage correlatedage dependentage linkedage relatedage specificagesalimentary tractalzheimer modelamyloid pathologyantibody titeringbio-markersbiologic markerbiological signal transductionbiomarkerblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablebowelbowel inflammationcerebral spinal fluidcohortdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldigestive canaldigestive tract microbiomedrivingeffective therapyeffective treatmententeric microbial communityenteric microbiomeenteric microbiotaexperimentexperimental researchexperimental studyexperimentsfecal samplefluidgastrointestinal microbial floragastrointestinal microbiomeglial activationglial cell activationgut communitygut dysbiosisgut floragut inflammationgut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehost responseimmune system responseimmunoneurologyimmunoresponseindexinginflamed bowelinflamed gutinflamed intestineinflammation markerinflammatory markerintestinal barrierintestinal biomeintestinal floraintestinal inflammationintestinal microbesintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal mucosal barrierintestinal tract microfloraliquidmTORmacromoleculemammalian target of rapamycinmetagenomemicrobialmicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremicrotubule bound taumicrotubule-bound taumouse modelmucousmurine modelneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneuroimmunologyneurological degenerationneuronal degenerationneuropathologicneuropathologicalneuropathologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approacholder adultolder adulthoodparticipant enrollmentpatient enrollmentpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprimary degenerative dementiaprospectivesenile dementia of the Alzheimer typesocial rolespinal fluidstool samplestool specimensuccesssystemic inflammationsystemic inflammatory responsetautau Proteinstau factorvirtualτ Proteins
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Description preview
The age-related processes that contribute to Alzheimer's disease (AD) development, particularly in the
prodromal period, are incompletely understood. Age-related reduction in gut microbiome alpha-diversity is
apparent in the majority of older adults, and is suspected of contributing to brain changes, including the
development of neurodegenerative…
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