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GRASP55 Regulates Pancreatic Beta-cell Golgi Structure and Function During Cytokine Stress
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Mar 2024Deadline 10 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025(TNF)-αAddressAdult-Onset Diabetes MellitusAffectAutoimmuneBeta CellBeta Proprotein Interleukin 1Brittle Diabetes MellitusCachectinCell BodyCell LineCell surfaceCellLineCellsCellular injuryChemicalsClinical TreatmentCouplingDataDefectDependenceDiseaseDisease ProgressionDisorderEarly InterventionEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEnzyme GeneEnzymesEventExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGORASP2GORASP2 geneGRASP55GeneticGolgiGolgi ApparatusGolgi ComplexGolgi Reassembly Stacking Protein 2Golgi Reassembly Stacking Protein, 55-KDHeat StressHumanHuntington ChoreaHuntington DiseaseHuntington'sHuntington's DiseaseHuntingtons DiseaseIDDMIFN-GammaIFN-gIFN-γIFNGIFNγIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βINOSImmuneImmune InterferonImmunesImpairmentInducible Nitric Oxide SynthaseInflammatoryInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusInterferon GammaInterferon Type IIInterleukin 1betaInterleukin-1 betaInterleukin-1βJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusKnock-outKnockoutLettersMacrophage Nitric Oxide SynthaseMacrophage-Derived TNFMaturity-Onset Diabetes MellitusMeasuresMediatingMentorsMetabolicMetabolic GlycosylationModelingModern ManMonocyte-Derived TNFMononitrogen MonoxideMorphologyNIDDMNOS2NOS2ANOS2A geneNOS2A, Inducible, HepatocyteNerve CellsNerve UnitNeural CellNeurocyteNeuronsNitric OxideNitric Oxide DonorsNitric Oxide Synthase 2ANitrogen MonoxideNitrogen ProtoxideNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusPancreatic beta CellPancreatic β-CellPathologicPathologyPathway interactionsPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreinterleukin 1 BetaProductionProtein ExportProtein Export PathwayProtein GlycosylationProtein ModificationProtein SortingsProtein TraffickingProtein-Folding DiseaseProteinsQuality ControlRegulationReportingResearchRodentRodentiaRodents MammalsRoleSecretory CellSite-Directed MutagenesisSite-Specific MutagenesisSlow-Onset Diabetes MellitusStable Diabetes MellitusStrains Cell LinesStressStructural ProteinStructureStructure of beta Cell of isletSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTargeted DNA ModificationTargeted ModificationTestingTumor Necrosis FactorTumor Necrosis Factor-alphaType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesUpregulationWorkadult onset diabetescell damagecell injurycellular damageclinical interventionclinical therapycultured cell linecytokinecytokine based immunotherapycytokine based therapycytokine immunotherapycytokine therapycytokine treatmentdamage to cellsendothelial cell derived relaxing factorexperimentexperimental researchexperimental studyexperimentsflow cytophotometryglycosylationinjury to cellsinsightinsulin dependent diabetesinsulin dependent type 1isletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabetesknock-downknockdownlFN-Gammamaturity onset diabetesmutantneo-antigenneo-epitopesneoantigensneoepitopesneuronalnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnitrosative stressnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpancreas beta cellpancreas β cellpancreatic b-cellpathwaypharmacologicpreventpreventingprotein folding disorderprotein misfolding diseaseprotein misfolding disorderprotein transportsecretory proteinsocial roletrial regimentrial treatmenttype 2 DMtype I diabetestype II DMtype one diabetestype two diabetesβ-cellβ-cellsβCell
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Description preview
ABSTRACT.
Type 1 Diabetes (T1D) results from autoimmune-mediated destruction of pancreatic β-cells. Currently, no long-
term treatments have been successful in preventing disease, and β-cell contribution to early pathology is
poorly understood. Early defects in β-cell secretory function, such as mis-trafficking of secretory proteins, are
evident…
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