grant
Gram-positive secretion chaperone-client interactions
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 8 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Bacterial PhysiologyBiologyChaperoneClientCyclophilinsCyclosporin-Binding ProteinsD pneumoniaeD. pneumoniaeDiplococcus pneumoniaeEnvironmentFamilyGeneHomologGoalsGram-Positive BacteriaGrantHomologHomologous GeneHomologueL monocytogenesL. monocytogenesListeria monocytogenesMembraneMolecularMolecular ChaperonesNutrientOrganismPPIasePeptidyl-Prolyl cis-trans-IsomerasePeptidylproline cis-trans-isomerasePeptidylprolyl IsomerasePneumococcusProcessProline IsomeraseProline RotamaseProlyl IsomeraseProtein SecretionProtein translocationRegulationResearchS pneumoniaeS. pneumoniaeStreptococcus pneumoniaeStressTransmembrane Protein Transportenvironmental changefascinateinsightliving systemmembrane structuremodel organismnovelprogramsprotein foldingtool
Description preview
Project Summary
Our research program focuses on post-translocation secretion chaperones in Gram-positive bacteria, so as
to better understand the processes underlying protein secretion, activity, and regulation following membrane
translocation. Currently, little is known about post-translocation protein folding in Gram-positive bacteria which…
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