grant
Glycomic Modulation of Inflammaging and Immune Functions during HIV Infection
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 15 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20257S Gamma GlobulinAACTGACTGAIDS VirusAIDS clinical trial groupAb-dependent cellular cytotoxicityAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcylneuraminyl hydrolaseAgingAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesArchivesAttenuatedBindingBiological MarkersBloodBlood Reticuloendothelial SystemBody TissuesCancersCarbohydratesCardiac DiseasesCardiac DisordersCell BodyCellsCellular Immune FunctionChronicClinicalCommunicationD-GalactoseDNADataDeoxyribonucleic AcidDevelopmentDiagnosisExhibitsFDA approvedFaceFc ReceptorGalactopyranoseGalactopyranosideGalactoseGeneral PopulationGeneral PublicGlycansGlycoengineeringGoalsHIVHIV AntibodiesHIV InfectionsHIV SeronegativitiesHIV SeronegativityHIV negativeHIV-Associated AntibodiesHTLV-III AntibodiesHTLV-III InfectionsHTLV-III SeronegativitiesHTLV-III SeronegativityHTLV-III-LAV AntibodiesHTLV-III-LAV InfectionsHealthHeart DiseasesHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntibodiesHuman T-Lymphotropic Virus Type III InfectionsIgGImmune systemImmunityImmunoglobulin GImpairmentInflammagingInflammationInflammatoryInflammatory ResponseInterruptionIntestinalIntestinesLAV AntibodiesLAV-HTLV-IIILinkLymphadenopathy-Associated AntibodiesLymphadenopathy-Associated VirusLymphatic cellLymphocyteLymphocyticMalignant NeoplasmsMalignant TumorMediatingMolecular InteractionMyeloid CellsN-Acetylneuraminic AcidsN-Acylneuraminate GlycohydrolasesNatureNeuraminidaseOligosaccharide SialidaseOutcomePersonsPolysaccharidesPrognostic MarkerPublicationsSamplingScientific PublicationSeveritiesSialic AcidsSialidaseStructureTestingTissuesViralVirusVirus-HIVacquired immunodeficiency syndrome clinical trial groupage associatedage correlatedage dependentage linkedage relatedage specificage-related inflammationaging associated inflammationameliorating inflammaginganti-inflammaginganti-viral immunityantibody dependent cell mediated cytotoxicityantibody dependent cytotoxicityantibody mediated cellular cytotoxicityantibody receptorantibody-dependent cell cytotoxicityantibody-dependent cellular cytotoxicityantibody-mediated cytotoxicityantiretroviral therapyantiretroviral treatmentantiviral immunityattenuateattenuate inflammagingattenuatesbio-markersbiologic markerbiomarkerbiomarker identificationbowelco-morbidco-morbiditycohortcomorbiditydevelopmentalexo alpha sialidasefacesfacialheart disorderhumanized micehumanized mouseidentification of biomarkersidentification of new biomarkersimmune functionin vivoinflamm-ageinginflamm-aginginflammaging mitigationinflammation associated with aginginhibitorinnate immune functionlymph cellmalignancymarker identificationmitigate age related inflammationneoplasm/cancernew approachesnovel approachesnovel strategiesnovel strategypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreservationpreventprevent age related inflammationprevent inflammagingpreventingpro-agingprogeronicprognostic biomarkerprognostic indicatorpromote agingreducing age related inflammationsenescencesenescentsialylationviral reboundvirus rebound
Description preview
PROJECT SUMMARY: There is an urgent need to identify biomarkers that can predict the development of
inflammation-associated comorbidities in people with HIV (PWH) on antiretroviral therapy (ART), as well as to
develop novel strategies to prevent or treat these comorbidities. Our recent data suggest that glycomic
alterations in circulating IgGs are…
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