grant
GLP-1R agonist immune targets in lean and obesity-associated asthma
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 16 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Adult-Onset Diabetes MellitusAgonistAllergensAmphoterinAmphoterin GeneAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAsthmaAttenuatedB Cell Differentiation Factor IB cell growth factorB cell growth factor 2B-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Growth Factor-IIB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCGF-IIBCGF2BCSF 1BSF-1BSF1Beta Proprotein Interleukin 1BinetrakinBiological MarkersBlood Platelet CountBlood Platelet NumberBlood PlateletsBlood SerumBlood leukocyteBronchial AsthmaCCL5CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessChemokine (C-C Motif) Ligand 5Chemotactic CytokinesChromosomal Protein, Nonhistone, HMG1Chromosomal Protein, Nonhistone, HMG1 GeneClinicalClinical DataClinical ResearchClinical StudyCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneD17S136EDataDiabetes MellitusDiseaseDisorderEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEo-CSFEosinophil Differentiation FactorExhalationExhalingExposure toFDA approvedFEV1FEV1%VCFM1 Gene ProductFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForced Expiratory Volume 1 TestForced Expiratory Volume in 1 SecondFrequenciesFundingGLP-1GLP-1 receptorGLP-I receptorGeneticGlp-1HMG-1HMG-1 GeneHMG-1 ProteinHMG1HMG1 GeneHMG3HMG3 GeneHMGB1HMGB1 ProteinHMGB1 geneHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHeparin-Binding Protein p30High Mobility Group Box Protein 1High Mobility Group Protein 1High Mobility Group Protein 1 GeneHigh-Mobility Group (Nonhistone Chromosomal) Protein 1High-Mobility Group (Nonhistone Chromosomal) Protein 1 GeneHigh-Mobility Group Box 1High-Mobility Group Box 1 GeneHomologous Chemotactic CytokinesHumanIL-1 betaIL-1 βIL-1-bIL-13IL-17IL-17 GeneIL-17AIL-17A GeneIL-1βIL-4IL-5IL1-BetaIL1-βIL13IL17IL17 ProteinIL17 geneIL17AIL17A GeneIL1B ProteinIL1F2IL1βIL4 ProteinIgA enhancing factorImmuneImmune TargetingImmunesImmunoassayImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIn VitroIndividualInducer CellsInducer T-LymphocytesInflammationInflammation MediatorsInflammatoryIntercrinesInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin 1betaInterleukin 5 PrecursorInterleukin-1 betaInterleukin-13Interleukin-17Interleukin-1βInterleukin-4Interleukin-4 PrecursorInterleukin-5Intervention StudiesIntracellular Communication and SignalingInvestigatorsKetosis-Resistant Diabetes MellitusLaboratoriesLeannessLeukocytesLeukocytes Reticuloendothelial SystemLymphocyte Stimulatory Factor 1MCGF-2MGC17164Marrow leukocyteMarrow plateletMast Cell Growth Factor-2Maturity-Onset Diabetes MellitusMeasuresMediatingMediatorMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsModern ManMononitrogen MonoxideMurineMusNIDDMNitric OxideNitrogen MonoxideNitrogen ProtoxideNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonhistone Chromosomal Protein HGM1Nonhistone Chromosomal Protein HGM1 GeneNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObese MiceObesityOutcomePFT/FEV1PathogenesisPathway interactionsPatientsPatternPhasePhenotypePlacebosPlatelet ActivationPlatelet CountPlatelet Count measurementPlatelet NumberPlatelet aggregationPlateletsPopulationPreinterleukin 1 BetaProductionProliferatingPublishingPulmonary Function Test/Forced Expiratory Volume 1RANTESRandomized, Controlled TrialsReceptor ProteinReceptor SignalingRefractory DiseaseResearchResearch PersonnelResearchersRespiratory ExpirationRiskRisk ReductionRoleSBP-1SBP-1 GeneSCYA5SIS cytokinesSIS deltaSIS-deltaSISdSamplingSerumSham TreatmentSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSmall Inducible Cytokine A5Stable Diabetes MellitusSteroid CompoundSteroidsSubcellular ProcessSulfoglucuronyl Carbohydrate Binding ProteinSulfoglucuronyl Carbohydrate Binding Protein GeneT cell replacing factorT-Cell ActivationT-Cell Growth Factor 2T-Cell RANTES ProteinT-Cell Replacing FactorT-Cell Specific Protein p288T-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT2 DMT2DT2DMT4 CellsT4 LymphocytesTCP228TestingTherapeuticThesaurismosisThinnessThrombocytesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVariantVariationViralWhite Blood CellsWhite Cellactivate T cellsadiposityadult onset diabetesairway epithelium inflammationairway inflammationasthma attackasthma exacerbationasthma patientasthmatic patientattenuateattenuatesbio-markersbiologic markerbiological signal transductionbiomarkercardiovascular riskcardiovascular risk factorcellular targetingchemoattractant cytokinechemokineco-morbidco-morbiditycohortcomorbiditycorpulencecytokinediabetesdiabetes riskendothelial cell derived relaxing factorexacerbation in asthmaexacerbation prone asthmaexacerbation prone asthmaticflow cytophotometryglucagon-like peptide 1glucagon-like peptide-1 receptorimprovedin vivoinflammatory mediatorinnovateinnovationinnovativeintervention researchinterventional researchinterventional studyinterventions researchketosis resistant diabeteslipid mediatorlung functionmaturity onset diabetesmetabolism disordernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetob/ob mouseobese asthmaobese individualsobese patientsobese peopleobese personobese populationobese subjectsobesity riskobesity-associated asthmaobesity-related asthmapathwaypatients with obesityperiostinperipheral bloodpharmacologicpre-clinical studyprecision medicineprecision-based medicinepreclinical studypulmonary functionrandomized control trialreceptorreceptor expressionreceptor functionreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrespiratory inflammationrespiratory tract inflammationresponseresponse biomarkerresponse markersrisk for obesityrisk of obesityrisk-reducingsample collectionsham therapysmall moleculesocial rolespecimen collectionthymus derived lymphocytetooltreatment strategytype 2 DMtype II DMtype two diabeteswhite blood cellwhite blood corpuscle
Description preview
Project Summary
Multiple preclinical and clinical studies show that glucagon-like peptide-1 receptor (GLP-1R) agonists, FDA
approved agents used in type 2 diabetes, obesity, and cardiovascular risk reduction, are a promising novel
treatment strategy for asthma. However, the key cellular targets and mechanisms by which GLP-1R agonists
reduce airway…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click