grant
Geospatially modeled environmental risk factors for lymphoid malignancies
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 15 Jan 2024Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202621+ years oldActive Follow-upAddressAdultAdult HumanAdult-Onset Diabetes MellitusAgeAir PollutantsApplication ContextAreaArsenicAutoimmune DiseasesB-Cell ActivationB-Cell CLLB-Cell Chronic Lymphocytic LeukemiaB-Cell Chronic Lymphogenous LeukemiaB-Cell Chronic Lymphoid LeukemiaB-Cell Lymphocytic LeukemiaB-Lymphocytic LeukemiaBMIBMI percentileBMI z-scoreBayesian MethodBayesian MethodologyBayesian Statistical MethodBayesian approachesBayesian classification methodBayesian classification procedureBayesian posterior distributionBenzeneBenzolBenzoleBiologic ModelsBiological ModelsBiometricsBiometryBiostatisticsBlood Plasma CellBody TissuesBody mass indexCLL Lymphoplasmacytoid LymphomaCadmiumCalendarCaliforniaCancer Prevention Study IICancersCausalityCd elementCellular Immune FunctionCessation of lifeChlorinated HydrocarbonsChronicChronic B-Lymphocytic LeukemiaChronic Lymphatic LeukemiaChronic Lymphoblastic LeukemiaChronic Lymphocytic LeukemiaChronic Lymphogenous LeukemiaCollaborationsConfounding Factors (Epidemiology)Confounding VariablesCox Proportional Hazards ModelsCyclohexatrieneDLBCLDataDeathDiagnosisDiffuse Large B-Cell LymphomaDioxin CompoundDioxinsDoseEcologic MonitoringEcological MonitoringEnvironmental EpidemiologyEnvironmental ExposureEnvironmental FactorEnvironmental MonitoringEnvironmental PollutantsEnvironmental Risk FactorEpidemiologic Confounding FactorEthnic OriginEthnicityEtiologyExposure AssessmentExposure toExposure to ultraviolet radiationFemale HealthFinancial HardshipFollow-Up StudiesGeneral PopulationGeneral PublicGeographic Information SystemsGerminoblastic SarcomaGerminoblastomaGrowth AgentsGrowth FactorGrowth SubstancesHealth Care ProfessionalHealth ProfessionalHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopathologyHematopoietic CancerHeterogeneityHistologicHistologicallyHistoryHumanImmuneImmune Cell ActivationImmune MarkersImmune PlasmaImmune systemImmunesImmunologic MarkersImmunomodulationIncidenceIndividualIndustrial WasteIndustrializationInflammationInfluentialsInfrastructureInvestigatorsJobsKetosis-Resistant Diabetes MellitusKnowledgeLife StyleLifestyleLymphocytic LymphomaLymphomaLymphoma, Lymphocytic, PlasmacytoidLymphoma, Lymphocytic, Well-DifferentiatedMalignant Hematologic NeoplasmMalignant LymphomaMalignant NeoplasmsMalignant TumorMalignant lymphoid neoplasmManuscriptsMature LymphocyteMaturity-Onset Diabetes MellitusMeasuresMedical HistoryMetalsMethodsModel SystemModelingModern ManModificationMultiple MyelomaNIDDMNeighborhoodsNon-Hodgkin's LymphomaNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonhodgkins LymphomaNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNurses' Health StudyNutritionOccupationalOccupational ExposureOccupationsOrganochlorine CompoundsOrganochlorinesPCBsParticipantPathogenesisPathogenicityPatientsPersonal Medical HistoryPersonal Medical History EpidemiologyPersonsPesticidesPlasma CellsPlasma-Cell MyelomaPlasmacytesPollutionPolychlorinated BiphenylsPolychlorobiphenyl CompoundsPopulation ResearchPopulation-based researchPopulation-level researchPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePredispositionPreventative strategyPrevention strategyPreventive strategyProfessional PositionsPropertyProspective StudiesProteins Growth FactorsPublic HealthPublishingQualifyingQuetelet indexRaceRacesRecording of previous eventsResearch PersonnelResearch ResourcesResearchersResidential MobilityResourcesReticulolymphosarcomaRiskRisk FactorsRoleSample SizeSlow-Onset Diabetes MellitusSmall B-Cell Lymphocytic LymphomaSmall Cell LymphomaSmall Lymphocytic LymphomaSmall-Cell LymphomaSmokingSolventsStable Diabetes MellitusSumSusceptibilityT2 DMT2DT2DMTimeTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUV Radiation ExposureUV exposureUltraviolet Radiation Related ExposureUltraviolet radiation exposureUnited StatesWomanWomen's HealthWorkactivated B cellsactive followupadult onset diabetesadulthoodafter menopauseagesarsenicsautoimmune conditionautoimmune disorderautoimmunity diseaseblack femaleblack womencancer diagnosiscancer epidemiologycancer preventioncarcinogenicitycausationchlorohydrocarbonchronic lymphoid leukemiaclinical relevanceclinically relevantcohortcontextual factorsdesigndesigningdisease causationeconomic hardshipeconomic strainenvironmental contaminantenvironmental riskenvironmental testingexposure analysisexposure evaluationexposure measurementexposure profilingexposure surveyexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesexpression subtypesfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial instabilityfinancial strainfinancial stressfinancial worryfollow upfollow-upfollow-up research studyfollow-up surveyfollowed upfollowing menopausefollowupgeospatial information systemhistoriesimmune activationimmune functionimmune modulationimmune regulationimmune-based biomarkersimmunologic reactivity controlimmunological biomarkersimmunological markersimmunomodulatoryimmunoregulationimmunoregulatoryindexingindustrial pollutantinsightinvestigate populationketosis resistant diabeteslarge cell Diffuse non-Hodgkin's lymphomalymphoid cancerslymphoid malignancymalignancymaturity onset diabetesmenmodel organismmolecular sub-typesmolecular subsetsmolecular subtypesmyelomamyelomatosisneoplasm/cancernon-Hodgkins diseasenovelobese individualsobese peopleobese personobese populationobese subjectspast menopauseplasmocytepollutantpolychlorobiphenylpopulation investigationpopulation level investigationpopulation specific researchpost-menopausalpostmenopausalpostmenopausal statusprospectiveprospective research studyprospective surveyracialracial backgroundracial originsexsocial rolesocio-demographic factorssocio-demographicssociodemographic factorssociodemographicsstudies of populationsstudy of the populationstudy populationstudy with follow-upsurvey populationteachertooltype 2 DMtype II DMtype two diabetesultraviolet exposureultraviolet light exposureunderstudied cancerworkplace exposure
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Project Summary/Abstract
Non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) are cancers arising from mature lymphocytes that
collectively pose a substantial public health, personal and financial burden. Present knowledge of their
etiology is inadequate to inform prevention strategies; data from prospective studies, and for specific histologic…
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