grant
Geometrical Regulation of Collective Cellular Responses in Three-Dimensional Space and Time
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 5 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAdipose tissueAffectAortic AneurysmAutoregulationBiochemicalBiomechanicsBlood VesselsBody TissuesCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsCellular MorphologyCollaborationsComputer ModelsComputerized ModelsCuesDevelopmentDevelopmental BiologyECMEducational AchievementEducational StatusEndotheliumEngineeringEnvironmentExpression SignatureExtracellular MatrixFatty TissueFoundationsFutureGene ExpressionGene Expression ProfileGene TranscriptionGenerationsGenetic TranscriptionGeometryGoalsGrafting ProcedureHomeostasisHumanImmuneImmunesIndividualInflammationIntracellular Communication and SignalingLengthMechanicsMesenchymalModern ManMorphogenesisNatural regenerationOrgan ModelOrgan TransplantationOrgan TransplantsPathway interactionsPatternPhysiologicPhysiologicalPhysiological HomeostasisPlayProliferatingRNA ExpressionRegenerationRegulationResearchRoboticsRoleScientistSignal TransductionSignal Transduction SystemsSignalingSkinSystemTechniquesTechnologyTestingTimeTissue EngineeringTissue constructsTissuesTranscriptionUniversitiesUterusWidthWorkadiposebio-fabricationbioengineered tissuebiofabricationbiological signal transductionbiomechanicalcell behaviorcell morphologycell typecellular behaviorcomputational modelingcomputational modelscomputer based modelscomputerized modelingconfocal imagingdevelopmentaleducational levelengineered tissuegene editing platformgene editing systemgene editing technologygene editing toolsgene expression patterngene expression signaturegene-editing toolkitmechanicmechanicalmigrationmorphogenetic processnano indentationnanoindentationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachorgan allograftorgan graftorgan xenograftpathwayprogramsregenerateregeneration biologyregenerative biologyresponsesecond harmonicself organizationsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthree dimensionaltissue woundtraining achievementtraining leveltraining opportunitytraining statustranscriptional profiletranscriptional signaturevascularwhite adipose tissuewombwoundwoundingwoundsyellow adipose tissue
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The self-organization and spatial patterning of cells are critical for tissue morphogenesis and regeneration. While biochemical factors have traditionally been the focus of developmental and regenerative biology research, emerging studies suggest that tissue geometry plays a pivotal role in controlling cellular behavior and tissue function. Our…
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