grant
Genomics of OCD in Latin American Communities
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 7 Jul 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AD/HDADHDASDActive Follow-upAddressAffectAllelesAllelomorphsAttention deficit hyperactivity disorderAutismAutistic DisorderBiologicalBiologyBrainBrain Nervous SystemCategoriesClinicalCommunitiesComplexDataData SetDevelopmentDiagnosisDiagnosticDimensionsDisablingDiseaseDisorderDysfunctionEarly DiagnosisEarly Infantile AutismEncephalonEnvironmental FactorEnvironmental Risk FactorEuropean ancestryExpression SignatureFunctional disorderFutureGWA studyGWASGene Expression ProfileGene FrequencyGene variantGene x Environment InteractionGenesGeneticGenetic DiversityGenetic ResearchGenetic RiskGenetic VariationGenetic studyGenomicsGoalsGxE interactionHealthHeritabilityHeterogeneityHeterozygoteHistoryImageIndividualInfantile AutismInheritance PatternsInternationalInvestigationInvestigatorsKanner's SyndromeLatin AmericanLatinoLinkMapsMental disordersMental health disordersMeta-AnalysisModelingMolecularNeurobiologyNeurodevelopmental DisorderNeurological Development DisorderObsessive-Compulsive DisorderObsessive-Compulsive NeurosisParentsPathway interactionsPatternPhasePhenotypePhilanthropic FundPhysiopathologyPopulationPopulation HeterogeneityPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPsychiatric DiseasePsychiatric DisorderPsychosocial FactorRecording of previous eventsReproducibilityResearchResearch PersonnelResearchersResolutionRiskRisk-associated variantRoleSample SizeSamplingSchizophreniaSchizophrenic DisordersSiteStructureTestingValidationVariantVariationWorkactive followupallelic frequencyallelic variantautism spectral disorderautism spectrum disorderautistic spectrum disorderbiologicbiomarker validationbrain tissuecase controlcase-controlledcohortdementia praecoxdevelopmentaldiscover genesdisease riskdisorder riskdiverse populationsearly detectioneffective interventioneffective therapyeffective treatmentenvironment effect on geneenvironmental riskexcitatory neuronexome sequencingexome-seqexposure to traumafollow upfollow-upfollowed upfollowupgene discoverygene environment interactiongene expression patterngene expression signaturegenetic architecturegenetic variantgenome resourcegenome sequencinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic datagenomic data resourcegenomic datasetgenomic resourcegenomic sequencing resourcegenomic variantheterogeneous populationheterozygosityhistoriesimagingimprovedin vivoinsightlow-frequency mutationmarker validationmental illnessmortalitymulti-modalitymultimodalitymultiomicsmultiple omicsneural imagingneuro-imagingneurobiologicalneurodevelopmental diseaseneuroimagingneurological imagingnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoffspringpanomicsparentpathophysiologypathwaypolygenetic risk scorespolygenic risk scorepopulation diversitypredictive toolsprobandpsychiatric genomicspsychiatric illnesspsychological disorderpsychosocial variablesrare allelerare mutationrare variantresolutionsrisk allelerisk generisk genotyperisk locirisk locusrisk variantschizophrenicsocial rolesuicidal risksuicide risksymptomatologytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptional profiletranscriptional signaturetranscriptomicstrauma exposurevalidationswhole genome association analysiswhole genome association studywork groupworking group
Description preview
PROJECT SUMMARY
In this study, I seek to understand how common and rare genetic variation influences the risk of developing
obsessive-compulsive disorder (OCD). OCD is a disabling psychiatric condition with unclear pathophysiology,
which has hindered the development of effective treatments and interventions. Although there is strong evidence
of…
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