grant
Genomic correlates of outcome in pleuropulmonary blastoma
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 12 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20250-11 years oldAffectAllelesAllelomorphsAssayBindingBioassayBiologicalBiological AssayCancer FamilyCancersCell BodyCell LineCellLineCellsCharacteristicsChildChild YouthChildhoodChildhood CancersChildren (0-21)ClinicalClinical DataCountryDICER GeneDICER1DICER1 geneDataDiagnosisDrug ScreeningDrugsEngraftmentEnrollmentEnzyme GeneEnzymesEventExhibitsExpression SignatureGene Expression ProfileGene TargetingGene TranscriptionGeneral Prognostic FactorGenesGeneticGenetic TranscriptionGenomicsGoalsHERNAHelicase with RNase MotifHelicase-MOIHeterograftHeterologous TransplantationHyperactivityImpairmentIn VitroIndividualInternationalK12H4.8-LikeKIAA0928Malignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant Tumor of the LungMalignant childhood cancerMalignant neoplasm of lungMeasuresMedicationMiceMice MammalsMicroRNAsMissense MutationModelingMolecularMolecular InteractionMurineMusOncogenicOperative ProceduresOperative Surgical ProceduresOutcomePDX modelPatient derived xenograftPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPharmaceutical PreparationsPleuropulmonary BlastomaPositionPositioning AttributePredispositionProcessProductionPrognosisPrognostic FactorPrognostic/Survival FactorProliferatingPulmonary CancerPulmonary malignant NeoplasmRNA ExpressionRadiationRecurrent diseaseRegistriesRelapsed DiseaseRepressionResearchRisk FactorsSentinelStrains Cell LinesSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTestingTherapeuticTranscriptionUnresectableVariantVariationXenograftXenograft procedureXenotransplantationarmbiologiccancer in a childcancer in childrencancer typechemotherapychild with cancerchildhood malignancyclinical effectclinical prognosisclinical riskcofactorcohortcultured cell linedrug/agentenrollgene expression patterngene expression signaturegenetic approachgenetic strategyimproved outcomein vivoinhibitorkidsloss of functionlung cancermalignancymiRNAmissense single nucleotide polymorphismmissense single nucleotide variantmissense variantneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpatient derived xenograft modelpatient oriented outcomespediatricpediatric cancerpediatric malignancyprognosticprognostic significanceprogramsresponserisk stratificationstratify risksurgerytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettranscriptional profiletranscriptional signaturetumortumor growthxeno-transplantxeno-transplantationyoungster
Description preview
Project Summary/Abstract
Pleuropulmonary blastoma (PPB) is the most common pediatric lung cancer in children and one of the
sentinel manifestations of DICER1-related tumor predisposition. While some patients with PPB may be treated
with surgery alone, children with advanced PPB require an intense combination of surgery, chemotherapy and
often…
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