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Genome-wide mechanisms and dynamics of ATP-dependent chromatin remodeling complexes
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025ARID1AARID1A geneAT- rich interactive domain-containing protein 1AAT-rich interactive domain 1A geneAcuteAddressAffectAutomobile DrivingBAF47BAF47 GeneBRG-1BRG-1 GeneBRG1BRG1 GeneBRM/SWI2-Related Gene-1Basal Transcription FactorBasal transcription factor genesBindingBiochemicalBioinformaticsBiological FunctionBiological ProcessBody TissuesBritish ColumbiaBudding YeastCUT&RUNCancersCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinChromatin Remodeling ComplexChromatin Remodeling FactorChromatin StructureCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseComplexDNADNA PackagingDNA mutationDataDefectDeoxyribonucleic AcidDevelopmentDiseaseDisorderES cell differentiationESC differentiationEndomycetalesEnhancersEnvironmentFamilyFoundationsFred Hutchinson Cancer Research CenterFrequenciesFutureGene ActivationGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomic SegmentGenomicsGoalsHeterogeneityHistonesHuman GenomeINI1INI1 GeneIndividualInvestigatorsKineticsKnowledgeLabelLeadLinkMNase-seqMalignant NeoplasmsMalignant TumorMapsMating Type Switching/Sucrose Nonfermenting ProteinMentorsMicrococcal nuclease digestion of chromatin followed by sequencingMicrococcal nuclease-sequencingMnase-SequencingModelingMolecularMolecular InteractionMolecular MachinesMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsMutationNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNucleosomesPRO-seqPb elementPhasePolycombPositionPositioning AttributePrecision Run-On SequencingPrecision nuclear run-on sequencingProcessProgenitor CellsProtein Complex SubunitProtein SubunitsProteinsRNA ExpressionRegulationRegulatory ElementRepressionResearchResearch PersonnelResearchersResidualResidual stateResolutionRoleSMARCA4SMARCA4 geneSMARCB1SMARCB1 geneSNF2-BetaSNF5SNF5 GeneSNF5L1SNF5L1 GeneSWI/SNF ComplexSWI/SNF Family ComplexSWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 GeneSWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 GeneSaccharomycetalesScientistSiteSpecificityStructureSubcellular ProcessSupervisionTechniquesTestingTimeTissuesTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationUniversitiesVariantVariationcell typechromatin modifierchromatin remodelingchromosomal locationchromosomal positionchromosome locationdesigndesigningdevelopmentaldevelopmental diseasedevelopmental disorderdifferentiation in embryonic stem cellsdrivingembryonic precursor differentiationembryonic stem cell differentiationepigenomicsexome sequencingexome-seqgenome mutationgenome scalegenome segmentgenome sequencinggenome-widegenomewidegenomic regionhSNF5/INI1 Geneheavy metal Pbheavy metal leadhuman whole genomein vivoinsightmESCmalignancymolecular imagingmolecule imagingmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellneoplasm/cancerneurological diseasenew approachesnovelnovel approachesnovel strategiesnovel strategypolybromopreferencepromoterpromotorrecruitresolutionssingle moleculesocial rolestem cellssuperresolution microscopytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factor
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PROJECT SUMMARY/ABSTRACT
The SWI/SNF family ATP-dependent chromatin remodelers are multi-subunit protein complexes that
dynamically position chromosomal nucleosomes to modulate DNA accessibility, transcription-factor binding,
and cell-type-specific gene expression. SWI/SNF function is crucial at several stages of mammalian
development, and recent…
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