grant
Genome Editing and Animal Models
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 25 Apr 1997Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20253R principles3Rs of animal researchAbscissionAdoptedAdvanced CancerAdvanced Malignant NeoplasmAnimal Experimental UseAnimal ExperimentationAnimal HusbandryAnimal ModelAnimal Models and Related StudiesAnimal ResearchAnimalsCCSGCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCancer CauseCancer CenterCancer Center Support GrantCancer EtiologyCancer ModelCancer TreatmentCancerModelCancersCell BodyCell LineCell modelCellLineCellsCellular modelCharacteristicsClonalityClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCommon Rat StrainsComplexComprehensive Cancer CenterCountryCryofixationCryopreservationDataData BasesDatabasesDedicationsDepositDepositionDerivationDerivation procedureDetectionDevelopmentDrug TherapyElectroporationEmbryoEmbryo TransferEmbryonicEmergenciesEmergency SituationEquipmentEquipment and supply inventoriesEthicsExcisionExhibitsExtirpationFamily suidaeFertilization in VitroFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFreezingFundingGUIDE-seqGenerationsGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenomeGenome-wide Unbiased Identification of DSBs Enabled by sequencingHumanImageInfrastructureInstitutionInstructionInternationalInventoryInvestigatorsLaboratoriesMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiceMice MammalsMicroinjectionsMissionModelingModern ManModernizationMonitorMouse StrainsMurineMusNeoplasm MetastasisPatientsPharmacological TreatmentPharmacotherapyPhenotypePigsProceduresRatRat StrainsRats MammalsRattusRecombinant DNA TechnologyRecoveryRemovalReplace, Reduce, RefineReplacement, Reduction, and RefinementReproductive BiologyResearchResearch PersonnelResearch ResourcesResearchersResource SharingResourcesRespondentRodentRodent ModelRodentiaRodents MammalsSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSamplingSecondary NeoplasmSecondary TumorServicesSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicStrains Cell LinesSuidaeSurgical RemovalSurvey InstrumentSurveysSwineSystemTechnologyTest-Tube FertilizationTrainingTransgenesTransgenic AnimalsTransgenic ModelUnited StatesUniversitiesUniversity resourcesVendorWisconsinWorkanalytical toolanimal experimentationsanti-cancer researchanti-cancer therapycancer metastasiscancer preventioncancer progressioncancer researchcancer therapycancer typecancer-directed therapyclustered regularly interspaced short palindromic repeats screencold preservationcold storagecoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccostcost effectivecultured cell linedata basedesigndesigningdevelopmentaldrug interventiondrug treatmentelectroporative deliveryembryo cryopreservationembryo freezingembryo transplantationembryonic cryopreservationembryonic freezingestablished cell lineethicalexperienceexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygene electrotransfergenetically engineeredgenome editinggenome scalegenome-widegenomewidegenomic editinghomologous recombinationhuman modelimagingimprovedindelinnovateinnovationinnovativeinsertion/deletioninsertion/deletion mutationmalignancymembermodel of animalmodel of humanneoplasm progressionneoplasm/cancerneoplastic progressionnovelpathogenpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsporcinepreservationpressurepreventpreventingprogramsreplace, reduce, and/or refinereplacing, reducing, refiningreproductiveresectionscreening servicessemen cryopreservationsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsomatic cell gene editingsomatic cell genome editingsomatic gene editingsomatic genome editingsperm cell cryopreservationsperm cryopreservationsperm freezingspermatozoa cryopreservationsuidtransgenetransgenic traittumor cell metastasistumor progression
Description preview
PROJECT SUMMARY / ABSTRACT
Genetically engineered animals and cell lines are widely used as models to define the mechanisms underlying
cancer etiology and progression and to evaluate strategies for cancer treatment and prevention. The Genome
Editing and Animal Models Shared Resource (GEAM) has served as a shared resource for the University of…
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