grant
Genetics, Epigenetics and Metabolism Research Program
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 15 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026AccelerationAchievementAchievement AttainmentAddressAgeAgingAreaAutomobile DrivingAwardBasic Cancer ResearchBasic ResearchBasic ScienceBiliaryBiochemistryBioinformaticsBiological ChemistryBiologyBrachydanio rerioBreast CancerCancer BurdenCancer ControlCancer Control ScienceCancer GenesCancer ModelCancer-Promoting GeneCancerModelCancersCatchment AreaCell BodyCell Communication and SignalingCell SignalingCell SurvivalCell ViabilityCellsChromatinClinical OncologyClinical TrialsCollaborationsColon CancerColon CarcinomaColon or RectumColorectalCommunicationCommunitiesCommunity OutreachComplementComplement ProteinsDNA mutationDanio rerioDefectDevelopmentDevelopmental TherapeuticsDevelopmental Therapeutics ProgramDevelopmental TherapyDiseaseDisorderDoctor of PhilosophyDrosophilaDrosophila genusDysmyelopoietic SyndromesElderlyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionFacultyFosteringFundingFutureGEM modelGEMM modelGI cancersGI malignanciesGI tract cancersGastrointestinal CancerGastrointestinal Tract CancerGene TranscriptionGenesGeneticGenetic ChangeGenetic EnhancementGenetic TranscriptionGenetic defectGenetic mutationGenetically Engineered MouseGenomeGenomicsGoalsGrantHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHepatic CancerImmune responseInstitutionIntermediary MetabolismInterventionIntracellular Communication and SignalingInvestigatorsLeadershipLength of LifeLinkLongevityMalignant Breast NeoplasmMalignant CellMalignant Gastrointestinal NeoplasmMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of gastrointestinal tractMalignant neoplasm of liverMalignant neoplasm of pancreasMediatorMentorsMentorshipMetabolicMetabolic MarkerMetabolic ProcessesMetabolismMissionMolecularMolecular GeneticsMutationMyelodysplastic DiseaseMyelodysplastic SyndromesNational Cancer BurdenNew YorkNon-Polyadenylated RNAOncogenesOncogenicOutcomeOxidative StressPancreasPancreas CancerPancreaticPancreatic CancerPeer ReviewPh.D.PhDPhasePhenotypePopulationPost-Transcriptional ControlPost-Transcriptional RegulationPostdocPostdoctoral FellowPre-Clinical ModelPreclinical ModelsProcessPublicationsPublishingQOLQuality ControlQuality of lifeRNARNA ExpressionRNA Gene ProductsRNA ProcessingRNA SplicingRecurrenceRecurrentRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsResearchResearch AssociateResearch PersonnelResearch ResourcesResearchersResource SharingResourcesRibonucleic AcidRoleRuralSchoolsScienceScientific PublicationSeriesSignal TransductionSignal Transduction SystemsSignalingSmoldering LeukemiaSplicingStrategic PlanningStrategic visionTherapeuticTherapeutic InterventionTrainingTraining ProgramsTranscriptionTransforming GenesTranslatingTranslational ResearchTranslational ScienceTranslationsTreatment-related toxicityTumor CellUniversitiesVariantVariationZebra DanioZebra FishZebrafishaccelerated agingaccelerated biological ageaccelerated biological agingaccelerated epigenetic ageaccelerated epigenetic agingaccelerated pace of epigenetic agingacceleration in epigenetic ageadvanced ageage accelerationagesaging induced epigenetic changeaging-associated epigenetic changeaging-related epigenetic changebiological signal transductioncancer cellcancer cell metabolismcancer in the coloncancer metabolismcancer microenvironmentcancer preventioncancer riskclinical translationclinically translatablecollaboration with communitiescolorectumcommunity collaborationcommunity engaged participatory researchcommunity engaged researchcommunity engagementcommunity partnered researchcommunity-based collaborationcommunity-engaged studycommunity-partnered studycomparative genomicscomplementationdevelopmentaldrivingengagement with communitiesepigenetic agingepigenetic biomarkerepigenetic markerepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingepigeneticallyepigenomeepigenomicsexperiencefaster epigenetic agingfaster rates of epigenetic agingfruit flyfunctional genomicsgastrointestinal malignanciesgenetically engineered mouse modelgenetically engineered murine modelgenome mutationgeriatrichost responseimmune system responseimmunoresponseimprovedincreased epigenetic ageincreased epigenetic agingincreased rates of epigenetic aginginnovateinnovationinnovativeinsightinter-institutionalintervention therapyleukemic transformationliver cancerliver malignancymalignancymalignant breast tumormalignant liver tumormeetingmeetingsmembermodel organismmultiomicsmultiple omicsmyelodysplasianeoplasm/cancerneoplastic cellnew drug treatmentsnew drugsnew markernew pharmacological therapeuticnew technologynew therapeuticsnew therapynext generationnext generation therapeuticsnovelnovel biomarkernovel drug treatmentsnovel drugsnovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel technologiesnovel therapeuticsnovel therapypancreatic cancer cellspancreatic malignancypancreatic tumor cellspanomicspost-docpost-doctoralpost-doctoral traineepost-transcriptional gene regulationpre-clinicalpre-clinical developmentpre-docpre-doctoralpreclinicalpreclinical developmentprogramsrapid epigenetic agingrecruitresearch associatessenior citizensocial rolestructural biologysynergismtherapeutic toxicitytherapy associated toxicitytherapy related toxicitytherapy toxicitytranslationtranslation researchtranslational impacttranslational investigationtreatment toxicitytreatment-associated toxicitytumor cell metabolismtumor metabolismtumor microenvironmentwork groupworking group
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GENETICS, EPIGENETICS AND METABOLISM RESEARCH PROGRAM: PROJECT SUMMARY/ABSTRACT
The Genetics, Epigenetics and Metabolism (GEM) research program aims to serve the mission of Wilmot Cancer Institute (Wilmot) through fundamental basic science research that provides new insight into the mechanisms that give rise to genetic and epigenetic…
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