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Genetic Variation and Inflammation-Dependent Hematopoietic Regulatory Networks
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Jan 2024Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025A fumigatusA. fumigatusAML - Acute Myeloid LeukemiaAML1AMLCR1AcuteAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAddressAffectAllelesAllelomorphsAnionic Neutrophil-Activating PeptideAspergillus fumigatusAttenuatedBacterial InfectionsBar CodesBasal Transcription FactorBasal transcription factor genesBlood Precursor CellBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationBone marrow failureCBFA2Cell Communication and SignalingCell SignalingCell WallCell surfaceChemotactic CytokinesChemotactic Factor, Neutrophil, Monocyte-DerivedChronicClinicalColony Stimulating Factor 3CoupledDNA mutationData SetDiseaseDisorderDysmyelopoietic SyndromesEmberger syndromeEngineeringEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFailureFocus GroupsFoundationsFungus DiseasesGATA2 deficiencyGATA2 haploinsufficiencyGCP-IL-8Gene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic DiversityGenetic ModelsGenetic TranscriptionGenetic VariationGenetic defectGenetic mutationGerm LinesGlycansGranulocyte Chemotactic Peptide-Interleukin-8Granulocyte Colony-Stimulating FactorHematologic Body SystemHematologic Organ SystemHematopoiesisHematopoieticHematopoietic Body SystemHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic Stem Cell MobilizationHematopoietic SystemHematopoietic progenitor MobilizationHematopoietic progenitor cell MobilizationHematopoietic stem cellsHeterozygoteHomologous Chemotactic CytokinesHumanImmunologic SubtypingImmunophenotypingImpairmentInfectionInflammationInflammatoryIntercrinesInterleukin-8Intracellular Communication and SignalingLeukocyte Adhesion InhibitorLibrariesLymphocyte-Derived Neutrophil-Activating PeptideM aviumM. aviumMacrophage-Derived Chemotactic FactorMarrow TransplantationMediatingMiceMice MammalsModelingModern ManMonoMACMonocyte-Derived Neutrophil-Activating PeptideMurineMusMutationMycobacterium aviumMycosesMyelodysplastic DiseaseMyelodysplastic SyndromesNeutrophil Activating PeptideNeutrophil Activation FactorNeutrophil Activation PeptideNeutrophil Chemotactic FactorNucleotidesPEBP2A2PEBP2aBPathogenesisPathogenicityPathway interactionsPatientsPilot ProjectsPluripoietinPolysaccharidesPopulationPredispositionProcessRNA ExpressionRUNX1RUNX1 geneRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsRepressionSIS cytokinesSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSmoldering LeukemiaSterilityStimulusStressSusceptibilitySyndromeSystemTestingTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransplantationVariantVariationViralViral DiseasesVirus DiseasesWild Type Mouseacute granulocytic leukemiaacute myeloid leukemiaattenuateattenuatesbacteria infectionbacterial diseasebarcodebiological signal transductionblood cell formationblood cell progenitorblood progenitorblood stem cellblood-forming stem cellbone marrow failure syndromechemoattractant cytokinechemokinechemotherapycytokinecytopeniadifferential expressiondifferentially expressedepigenetic gene silencingepigenetic silencingepigeneticallyextracellularfungal infectionfungus infectiongalactosaminogalactangenome mutationgranulocyte colony stimulating factorhematopoietic differentiationhematopoietic progenitorhematopoietic stem and progenitor cell mobilizationhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellheterozygosityhuman modelhypoimmunityimmune deficiencyimmunodeficiencyinfection recurrenceinsightmimeticsmodel of humanmouse modelmurine modelmyelodysplasiaopportunistic pathogenpathogenpathwayperipheral bloodpilot studypreventpreventingprogenitor biologyprogenitor cell biologyprogenitor cell expansionprogenitor cell functionprogenitor cell poolprogenitor cell populationprogenitor expansionprogenitor functionprogenitor poolprogenitor populationrecurrent infectionrecurring infectionresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle nucleotide variantsingle-cell RNA sequencingstem and progenitor biologystem and progenitor cell expansionstem and progenitor cell functionstem and progenitor cell populationstem and progenitor functionstem cell biologystem cell expansionstem cell functionstem cell poolstem cell populationsteriletranscription factortranscriptional differencestransplantviral infectionvirus infectionvirus-induced diseasewildtype mouse
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Description preview
PROJECT SUMMARY
Transcription factors and cellular signaling mechanisms establish and maintain regulatory networks that allow
the hematopoietic system to respond to infection, inflammation and other stresses. These networks mediate the
expansion, mobilization, and differentiation of hematopoietic stem and progenitor cells (HSPCs). As exemplified…
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