grant
Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Jan 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20259p21ABH Blood GroupABO blood group systemABO blood groupsABO(H) blood groupsAPOEASCVDAddressAffectAortaApo-EApoE proteinApolipoprotein EApoplexyAtherosclerosisAtherosclerotic Cardiovascular DiseaseBioenergeticsBioinformaticsBiologicalBrain Vascular AccidentCandidate Disease GeneCandidate GeneCardiacCardiac DiseasesCardiac DisordersCardiac infarctionCarotid Artery NarrowingCarotid Artery StenosisCarotid StenosisCause of DeathCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChromosomesClassificationCollaborationsCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisDNA ContentDNA IndexDNA PloidyDataDevelopmentECMEDN1ET-1Endothelin Type 1Endothelin-1EventExhibitsExtracellular MatrixFollow-Up StudiesFollowup StudiesFoundationsGWA studyGWASGenesGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic predisposing factorGenetic propensityGenetic studyGenomicsH Blood GroupH Blood Group SystemHeart DiseasesHumanIndividualInherited PredispositionInherited SusceptibilityIntracellular Communication and SignalingLeadLeiomyocyteLesionMapsMeta-AnalysisMiceMice MammalsMitochondrial DNAModern ManMolecularMurineMusMyocardial InfarctMyocardial InfarctionPathway interactionsPatientsPatternPb elementPlaque RupturePloidiesPredisposition geneProbabilityProductionRNA SeqRNA sequencingRNAseqRegional DiseaseRiskRoleSeriesSignal TransductionSignal Transduction SystemsSignalingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSocietiesStrokeSudden DeathSurgical ModelsSusceptibility GeneSystematicsTestingValidationVariantVariationatheromatosisatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic plaque ruptureatherosclerotic vascular diseasebiologicbiological signal transductionbrain attackcardiac infarctcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcerebral vascular accidentcerebrovascular accidentchromosome complementclinical significanceclinically significantcohortcomparativecoronary arterial diseasecoronary attackcoronary infarctcoronary infarctiondevelopmentaldiscover genesexomeexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgene discoverygenetic analysisgenetic approachgenetic etiologygenetic mechanism of diseasegenetic risk factorgenetic strategygenetic vulnerabilitygenetically predisposedgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyheart attackheart disorderheart infarctheart infarctionheavy metal Pbheavy metal leadhuman modelin vivoinherited factorinnovateinnovationinnovativelow-frequency mutationmigrationmodel of humanmouse modelmtDNAmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypredisposing generare allelerare mutationrare variantsocial rolestrokedstrokessusceptibility allelesusceptibility locussusceptibility varianttherapeutic agent developmenttherapeutic developmentthrombotictranscriptome sequencingtranscriptomic sequencingvalidationswhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY
Myocardial infarction (MI) and coronary artery disease (CAD) are the leading causes of death in Western
societies. Individuals with CAD are typically asymptomatic, with the first manifestations often being major
adverse cardiac events (MACE), such as MI, stroke, or sudden death due to the rupture of an atherosclerotic
plaque.…
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