grant
Genetic Modifiers of Atherosclerosis: Understanding and Targeting the Mechanism of the ApoER2-R952Q Mutation
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026APOEAPOE e4APOE-ε4APOEε4ASCVDAcute myocardial infarctAcute myocardial infarctionAddressAdhesion MoleculeAdhesionsAdverse effectsAffectAgingAntibodiesApo-EApoE proteinApolipoprotein EApoplexyApproaches to preventionArteriesAssayAtherosclerosisAtherosclerosis-proneAtherosclerosis-susceptibleAtherosclerotic Cardiovascular DiseaseAutomobile DrivingBB2Basal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBloodBlood PlasmaBlood Reticuloendothelial SystemBlood VesselsBlood leukocyteBlood monocyteBrain Vascular AccidentCD106CD106 AntigensCD54CD54 AntigensCD62E AntigensCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCarotid Artery Ulcerating PlaqueCarotid UlcersCause of DeathCell Adhesion Molecule E-SelectinCell Adhesion Molecule GeneCell Adhesion MoleculesCell Communication and SignalingCell Culture TechniquesCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeCholesterolCholesterol HomeostasisCoronary DiseaseCoronary heart diseaseCuesDNA mutationDataDeathDevelopmentDiabetes MellitusDyslipidemiasE-SelectinEDRF SynthaseELAM-1Endothelial Adhesion Molecule 1Endothelial CellsEndothelial Leukocyte Adhesion Molecule-1EndotheliumEndothelium-Derived Growth Factor SynthaseEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationExtracellular ProteinFamilyFoam CellsGatekeepingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGoalsGuanylyl Cyclase-Activating Factor SynthaseHeart VascularHumanHypertensionICAM-1ICAM-1 GeneICAM1ICAM1 geneINCAM-110Immune SurveillanceImmunologic SurveillanceImmunosurveillanceInducible Cell Adhesion Molecule 110InfiltrationInflammationInflammatoryIntercellular adhesion molecule 1Intracellular Communication and SignalingJointsKnowledgeLDL CholesterolLDL Cholesterol LipoproteinsLDL ReceptorsLDLR geneLECAM-2LR7-8BLRP8 proteinLesionLeucocytic infiltrateLeukocyte Endothelial Cell Adhesion Molecule 2LeukocytesLeukocytes Reticuloendothelial SystemLigandsLinkLipidsLipoprotein LDL ReceptorsLow Density Lipoprotein CholesterolLow Density Lipoprotein ReceptorMacrophageMarrow leukocyteMarrow monocyteMethodsMiceMice MammalsModern ManMolecular InteractionMurineMusMutationMyocardial InfarctMyocardial InfarctionMφNO SynthaseNitric Oxide SynthaseNitric-Oxide SynthetaseNuclearObstructionOrganPathologyPathway interactionsPatientsPeripheral arterial diseasePermeabilityPlasmaPlasma SerumPlayPopulationPopulation HeterogeneityPredispositionPreventative therapyPrevention approachPreventive therapyProgressive DiseaseProne to atherosclerosisPropertyPublicationsRNA SeqRNA sequencingRNAseqResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRoleScientific PublicationSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSingle Base PolymorphismSingle Nucleotide PolymorphismStrokeSusceptibilityTestingTherapeuticThrombosisTranscription Factor Proto-OncogeneTranscription factor genesTriacylglycerolTriglyceridesVCAMVCAM-1VariantVariationVascular Cell Adhesion MoleculeVascular Cell Adhesion Molecule-1Vascular DiseasesVascular DisorderVascular Hypertensive DiseaseVascular Hypertensive DisorderWhite Blood CellsWhite CellWorkapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apoER2apolipoprotein E epsilon 4apolipoprotein E receptor 2apolipoprotein E receptor 2 gene productapolipoprotein E-4apolipoprotein E4arterial remodelingarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessatheromatosisatheroproneatherosclerotic diseaseatherosclerotic vascular diseasebeta-Lipoprotein Cholesterolbiological signal transductionblood vessel disorderbrain attackcardiac infarctcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcell adhesion proteincell culturecell culturescell typecerebral vascular accidentcerebrovascular accidentcholesterol metabolismchronic inflammatory diseasecirculatory systemclinical applicabilityclinical applicationcoronary attackcoronary disordercoronary infarctcoronary infarctiondevelopmentaldiabetesdiverse populationsdrivingendothelial dysfunctionendothelial leukocyte adhesion moleculeethnic subgroupethnicity groupgain of functiongain of function mutationgatekeepergenome mutationheart attackheart infarctheart infarctionheterogeneous populationhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderin vivoinsightloss of function mutationlow density lipoprotein receptor-related protein 8monocytemouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayperipheral artery diseasepolymorphismpopulation diversitypremature atherosclerosispreventpreventingsingle nucleotide variantsocial rolestrokedstrokessusceptibility to atherosclerosistargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targetthrombotic diseasethrombotic disordertranscription factortranscriptome sequencingtranscriptomic sequencinguptakevascularvascular corrosion plaquesvascular dysfunctionvascular erosion plaquesvascular inflammationvascular plaquevasculopathywhite blood cellwhite blood corpuscle
Description preview
PROJECT SUMMARY
The scientific understanding of blood vessels has evolved significantly over the decades. They are now
recognized as active gatekeepers that control organ function rather than passive conduits responding to external
cues. Endothelial dysfunction is implicated in various pathologies, including atherosclerosis, which is a…
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