grant

Genetic mechanisms of snail/schistosome compatibility

Organization OREGON STATE UNIVERSITYLocation CORVALLIS, UNITED STATESPosted 10 Jan 2019Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectAllelesAllelomorphsAustralorbisBilharziaBilharziasisBindingBiomphalariaCRISPRCRISPR/Cas systemCandidate Disease GeneCandidate GeneCausalityChronic DiseaseChronic IllnessChronic disabilityClustered Regularly Interspaced Short Palindromic RepeatsCodeCoding SystemCountryDNA SequenceDataDoseDrug resistanceDrugsEtiologyFunctional RNAGWA studyGWASGenerationsGenesGeneticGenetic DiversityGenetic PolymorphismGenetic VariationGenome ScanGenomic SegmentGeographyGoalsHaplotypesHelminthsHomozygoteImmune responseImmunologyInbreedingIndividualInfectionInterruptionKnock-outKnockoutKnowledgeLigandsLinkLocationMapsMedicationMethodsModernizationModificationMolecularMolecular InteractionNamesNatural ResistanceNoncoding RNANontranslated RNAParasitesParasitic DiseasesParasitic WormsPathway interactionsPersistent disabilityPersonsPharmaceutical PreparationsPoisonPopulationPost-Transcriptional Gene SilencingPredispositionPredisposition geneQTLQuantitative Trait LociRNA InterferenceRNA SeqRNA SilencingRNA sequencingRNAiRNAseqResearchResistanceResistance to infectionS mansoniS. mansoniSchistosomaSchistosoma Mansoni InfectionSchistosoma mansoniSchistosoma mansonii infectionSchistosomatidaeSchistosomeSchistosomiasisSchistosomiasis mansoniSequence-Specific Posttranscriptional Gene SilencingSideSnaH proteinSnailsSusceptibilitySusceptibility GeneSystemTestingToxic ChemicalToxic SubstanceTransmissionUntranslated RNAVaccinesVariantVariationWorkblood flukecausationchronic disorderdisease causationdrug resistantdrug/agenteffective therapyeffective treatmentgene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome segmentgenome wide associationgenome wide association scangenome wide association studygenome-wide scangenomewide association scangenomewide association studygenomewide scangenomic regionhost responsehuman diseaseimmune system responseimmunoresponseinfection resistancenamenamednamingnaturally resistantnew approachesnoncodingnovel approachesnovel strategiesnovel strategypathwaypolymorphismpredisposing geneprofound disabilitypublic health relevanceresistance generesistance locusresistance strainresistance to Drugresistantresistant generesistant strainresistant to Drugserious disabilitysevere disabilitysna gene productsna proteinsnail gene productsnail proteinsusceptibility allelesusceptibility locussusceptibility varianttoxic compoundtraittranscriptome sequencingtranscriptomic sequencingtransmission blockingtransmission processwater-bornewaterbornewhole genome association analysiswhole genome association studywhole-genome scan
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Description preview

Schistosomiasis is by far the most important helminth parasitic disease of humans. Vaccines are unavailable,
the only effective treatment involves repeated dosing with a single drug, and drug resistance is now a major

concern. Schistosomes require aquatic snails for transmission. Mass drug administration alone has proven

ineffective at eliminating…

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