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Genetic control of mature beta cell function and identity
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Dec 2021Deadline 30 Nov 2025 β οΈ
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAdult-Onset Diabetes MellitusAffectBehaviorBeta CellBiological FunctionBiological ProcessBrittle Diabetes MellitusCausalityCell FunctionCell MaturationCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChronic stressCollaborationsConsensusCoupledDNA TherapyData SetDevelopmentDiabetes MellitusDiseaseDisorderDrug TherapyDysfunctionEtiologyFailureFunctional disorderGene ExpressionGene TranscriptionGene Transfer ClinicalGeneralized GrowthGenesGeneticGenetic InterventionGenetic TranscriptionGoalsGrowthHumanIDDMIn VitroInsulin CellInsulin ResistanceInsulin Secreting CellInsulin-Dependent Diabetes MellitusJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusLineage TracingMapsMaturity-Onset Diabetes MellitusMetabolic stressMiceMice MammalsModelingModern ManMurineMusNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityPancreasPancreaticPeripheralPharmacological TreatmentPharmacotherapyPhenotypePhysiopathologyProcessProgenitor CellsRNA ExpressionRNA SeqRNA sequencingRNAseqReportingSignal PathwaySlow-Onset Diabetes MellitusStable Diabetes MellitusStressSubcellular ProcessSudden-Onset Diabetes MellitusSystemT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTestingTissue GrowthTranscriptionType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesadiposityadult onset diabetesadulthoodautoimmune attackautoimmune destructionautoimmune pathogenesisblood glucose regulationcausationcell dedifferentiationcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingcomputer based predictioncorpulencedata driven platformdata platformdevelopmentaldiabetesdiabeticdiabetogenicdisease causationdrug interventiondrug treatmentenvironmental stressesenvironmental stressorfunctional restorationgene repair therapygene therapygene-based therapygenetic therapygenomic therapyglucose controlglucose homeostasisglucose regulationin vivoinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin secretioninsulin toleranceisletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabetesmaturity onset diabetesmouse modelmurine modelnovelontogenypathophysiologypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-natal developmentpostnatal developmentpredictive modelingpreventpreventingrestore functionrestore functionalityrestore lost functionstem cellstranscriptome sequencingtranscriptomic sequencingtype 1 and type 2 diabetestype 2 DMtype I and type II diabetestype I diabetestype II DMtype one diabetestype two diabetesΞ²-cellΞ²-cellsΞ²Cell
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Project Summary/Abstract
Functionally mature beta cells are essential to glucose homeostasis and their loss or dysfunction underlies all
types of diabetes mellitus. In recent years, it has become clear that not all beta cells are permanently lost in
either type of diabetes. Instead, chronically stressed beta cells lose their functionally matureβ¦
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