grant
Genetic control of developmental timing
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 May 2019Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026AnimalsBasal Transcription FactorBasal transcription factor genesC elegansC. elegansC.elegansCaenorhabditis elegansCell BodyCell Growth in NumberCell LineageCell MultiplicationCell ProliferationCellsCellular ProliferationCollaborationsComplexDevelopmentElementsEventFoodFunctional RNAGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic studyGenomicsLarvaLife StyleLifestyleMicroRNAsMorphogenesisNatural regenerationNematodaNematodesNoncoding RNANontranslated RNAOrganismPatternPhenotypePhysiologicPhysiologicalProliferatingRNA-Binding ProteinsRegenerationRegulator GenesResearchRoleSoilSpecific qualifier valueSpecifiedStressSystemTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional Regulatory ElementsUntranslated RNAWorkcell fate specificationcell typedevelopmentalenvironmental stressesenvironmental stressorgenetic trans acting elementliving systemmiRNAmicrobialmorphogenetic processmutantnoncodingphysiologic stressesphysiologic stressorphysiological stressesposttranscriptionalprogramsregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregulatory genereplacement tissueresilienceresilientresilient to stressroundwormsocial rolespatial and temporalspatial temporalspatiotemporalstress resiliencestress resiliencysuccesstissue regenerationtissue regrowthtissue renewaltissue specific regenerationtrans acting elementtranscription factor
Description preview
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Project Summary/Abstract
Development of even the simplest of multicellular animals is astonishingly complex, involving the spatial
and temporal orchestration of cellular proliferation, differentiation, and morphogenesis throughout the
developing organism. The success of the species demands that its developmental programs are robust and…
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