grant
Genetic and Molecular Mechanisms of Heart Disease
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 15 Apr 2025Deadline 31 Jan 2032
NIHUS FederalResearch GrantFY2026AddressArrhythmiaBinding SitesBiologicalBiologyBody TissuesCardiacCardiac ArrhythmiaCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiocyteCardiomyopathiesCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell Death InductionCessation of lifeClinicalCombining SiteDataDeathDiseaseDisorderEventFunctional RNAGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesGeneticGoalsHealth Care SystemsHeartHeart ArrhythmiasHeart DiseasesHeart Muscle CellsHeart VascularHeart failureHeart myocyteIncidenceIntermediary MetabolismIon ChannelIonic ChannelsIschemiaIschemia-Reperfusion InjuryIschemic HeartIschemic Heart DiseaseIschemic myocardiumKnowledgeLinkMediatingMembrane ChannelsMetabolic ProcessesMetabolismMethodsMicroRNAsMitochondriaMolecularMorbidityMuscleMuscle TissueMyocardial DiseasesMyocardial DisorderMyocardial IschemiaMyocardial Ischemic Reperfusion InjuryMyocardial Reperfusion InjuryMyocardiopathiesNamesNoncoding RNANontranslated RNAOutcomeOxidative StressPathologic ProcessesPathological ProcessesPathologyPathway interactionsPatientsPermeabilityPlayPredispositionPrevalenceProteinsPublic HealthReactive SiteRegulationReperfusion DamageReperfusion InjuryReperfusion TherapyResearchRespirationRiskRoleSodium ChannelSodium Ion ChannelsStressSusceptibilityTestingTherapeuticTissuesUntranslated RNAWomanbiologiccardiac failurecardiac ischemiacardiomyocytecirculatory systemclinical careclinical relevanceclinical significanceclinically relevantclinically significantcoronary ischemiacostcyclosporin A-SPTPcyclosporin A-sensitive pereability transition poreheart disorderheart ischemiahuman diseaseimprovedmenmiRNAmitochondrialmitochondrial megachannelmitochondrial membranemitochondrial permeability transition poremortalitymuscularmyocardial ischemia/hypoxiamyocardium diseasemyocardium disordermyocardium ischemianamenamednamingnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnoncodingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpathwayprogramspublic health relevancereperfusionrespiratory mechanismresponsesocial rolesudden cardiac deathtranslational impact
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PROJECT SUMMARY / ABSTRACT
Heart disease is a leading cause of morbidity and mortality, and the incidence of heart failure (HF) is growing, while
costing our public healthcare system over $30B per year. HF coincides with significant perturbations in cardiac gene
regulation, mitochondrial function, and ion channel expression and activity, and my…
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