grant
Genetic and Gut Microbial Regulation of Indole-3 Propionate in Metabolic Disease
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 6 Apr 2026Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY20262,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors3-PyridinecarboxamideAH ReceptorsAcid-Thiol LigasesActive Follow-upAcyl CoA SynthetasesAcyl Coenzyme A SynthetasesAddressAdipose tissueAdult-Onset Diabetes MellitusAnimal ExperimentsAnimal ModelAnimal Models and Related StudiesAppetite RegulationAryl Hydrocarbon ReceptorAttenuatedAutoregulationBacteriaBifidobacteriumBioinformaticsBiologicalBlood PlasmaBody TissuesCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChromosome 16ChromosomesClinical ResearchClinical StudyClinical TrialsClostridiumCo A LigasesCoenzyme A LigasesCoenzyme A SynthetasesComplexDietDietary FactorsDietary IndoleDihydronicotinamide Adenine DinucleotideDioxin ReceptorsDiphosphopyridine NucleotideDrug PrecursorsEngineeringEnzyme GeneEnzymesFatty TissueGEM modelGEMM modelGI microbiotaGWA studyGWASGastrointestinal microbiotaGene ModifiedGenesGeneticGenetic DeterminismGenetic studyGenetically Engineered MouseGerm-FreeGlucose IntoleranceGnotobioticGnotobioticsGoalsHealthHigh Fat DietHomeostasisHumanHuman ChromosomesIn VitroIndividualIndolesInsulin ResistanceIntermediary MetabolismIntestinalIntestinesIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKnowledgeL-TryptophanLactaseLactase EnzymeLactose GalactohydrolaseLevotryptophanLiverMaintenanceMapsMaturity-Onset Diabetes MellitusMediatingMediatorMedium chain fatty acidMendelian randomizationMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsModern ManMolecularMurineMusNIDDMNadideNiacinamideNicotinamideNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideNicotinamidumNicotinic acid amideNicotylamideNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNuclear TranslocatorNutrientObesityOutcomePancreatic beta CellPancreatic β-CellPathway interactionsPellagra-Preventing FactorPhysiological HomeostasisPlasmaPlasma SerumPolyaromatic Hydrocarbon ReceptorsPro-DrugsProdrugsProductionPropionatesPropionic AcidsRegulationReproducibilityReticuloendothelial System, Serum, PlasmaRiskRoleSignal TransductionSignal Transduction SystemsSignalingSilent Mating Type Information Regulator 2-like ProteinsSir2-like ProteinsSirtuinsSkeletal MuscleSlow-Onset Diabetes MellitusStable Diabetes MellitusStructure of beta Cell of isletSubcellular ProcessSupplementationSystemT2 DMT2DT2DMTCDD ReceptorsTaxonTestingTherapeuticThesaurismosisTissuesTransferaseTransferase GeneTryptophanTryptophan MetabolismTryptophan Metabolism PathwayType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUpregulationValidationVariantVariationVitamin B 3Vitamin B3Vitamin PPVoluntary Muscleactive followupadiposeadiposityadult onset diabetesanimal experimentattenuateattenuatesbacteria in the gutbacterial communitybiologicbiological signal transductionbowelcorpulencedietarydietsenteric microbial communityenteric microbiotaexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentsfeedingfollow upfollow-upfollowed upfollowupgastrointestinal homeostasisgastrointestinal microbial floragene modificationgenetic architecturegenetic determinantgenetically engineered mouse modelgenetically engineered murine modelgenetically modifiedgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglucose metabolismglucose tolerancegut bacteriagut communitygut floragut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiotagut microbioticgut microflorahepatic body systemhepatic organ systemhuman modelimprovedin vivoinnovateinnovationinnovativeinsightinsulin resistantinsulin sensitivityinsulin toleranceintestinal barrierintestinal floraintestinal homeostasisintestinal microbesintestinal microbiotaintestinal microfloraintestinal mucosal barrierintestinal tract microfloraketosis resistant diabeteslow-frequency mutationmaturity onset diabetesmembermetabolic phenotypemetabolism disordermetabotypemicrobialmodel of animalmodel of humanmouse modelmurine modelmutantnovelpancreas beta cellpancreas β cellpancreatic b-cellpathwayphenomepre-clinicalpreclinicalpreventpreventingpropanoic acidprotective effectrare allelerare mutationrare variantresponserestorationsocial rolethiokinasetraittype 2 DMtype II DMtype two diabetesvalidation studiesvalidationswhite adipose tissuewhole genome association analysiswhole genome association studyyellow adipose tissue
Description preview
PROJECT SUMMARY
Metabolic diseases, such as obesity and type 2 diabetes (T2D), are characterized by perturbations of glucose
tolerance, pancreatic beta cell function, energy imbalance, appetite regulation, and other unknown pathways.
Clinical and genetic studies in humans and animal experiments have also implicated gut microbiota and products…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click