grant
Genetic and Epigenetic Programming of Allergic Airway Inflammation
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 1998Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025ASH ProteinAberrant TissueAbundant SRC HomologyAddressAffectAllergensAllergic inflammationAlveolar MacrophagesAsthmaAutomobile DrivingB cell differentiation factorB cell growth factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-1B-Cell Differentiation Factor-2B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-Cell Stimulatory Factor-2BCDFBCDF-1BCGFBCGF-1BCSF 1BMIBMI percentileBMI z-scoreBSF-1BSF-2BSF1BSF2BinetrakinBiologyBlood SampleBlood specimenBody TissuesBody mass indexBronchial AsthmaCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessChoristomaChronicCoupledCuesEctopic TissueEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionExposure toGRB-2GRB2GRB2 ProteinGRB2 adaptor proteinGRB2 geneGenerationsGeneticGrowth AgentsGrowth FactorGrowth SubstancesHPGFHepatocyte-Stimulating FactorHeterotopic TissueHigh PrevalenceHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-13IL-4IL-6IL13IL4 ProteinIL6 ProteinImmuneImmune ToleranceImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologic ToleranceImmunologicalImmunologicallyImmunologicsImmunomodulationImpairmentIndividualIndustrializationInflammationInflammatoryInnate Immune ResponseInterleukin-13Interleukin-4Interleukin-4 PrecursorInterleukin-6Intracellular Communication and SignalingLicensingLifeLife StyleLifestyleLigandsLinkLungLung InflammationLung ParenchymaLung Respiratory SystemLung TissueLymphocyte Stimulatory Factor 1MCGF-2MGI-2Mast Cell Growth Factor-2MediatingModern ManMyeloid Differentiation-Inducing ProteinNon-Polyadenylated RNAObesityParticulate MatterPathogenesisPathologyPathway interactionsPatientsPlasmacytoma Growth FactorPlayPneumonitisPredispositionPredisposition geneProcessProductionPropertyProteinsProteins Growth FactorsPulmonary InflammationPulmonary MacrophagesQuetelet indexRNARNA Gene ProductsReceptor ProteinRegulationRegulatory T-LymphocyteRibonucleic AcidRoleSignal TransductionSignal Transduction SystemsSignalingSocial ChangeSocial modificationSocial transformationSourceStructure of parenchyma of lungSubcellular ProcessSusceptibilitySusceptibility GeneT-Cell Growth Factor 2Th-2 CellTh2 CellsTissuesTregType 2 Helper CellVariantVariationViralViral DiseasesViral Respiratory Tract InfectionVirusVirus ActivationVirus DiseasesVirus InductionWNT Signaling PathwayWNT signalingabundant Src homology proteinadaptive immune responseadiposityairway epithelium inflammationairway inflammationallergic airway epithelium inflammationallergic airway inflammationasthmaticbiological signal transductioncohortcorpulencecytokinedifferentiation factorsdrivingenvironmental changeepigeneticallygrowth factor receptor-bound protein 2host responseimmune functionimmune modulationimmune regulationimmune system responseimmune system toleranceimmune unresponsivenessimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinterferon beta 2morphogenic factorsmorphogensmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnotchnotch proteinnotch receptorsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyobese asthmaobesity-associated asthmaobesity-related asthmaparticlepathwaypollutantpredisposing genereceptorregulatory T-cellsrespiratory inflammationrespiratory tract inflammationrespiratory virussocial rolesusceptibility allelesusceptibility locussusceptibility variantsynergismtissue repairtissue-repair responsesviral activationviral inductionviral infectionviral respiratory infectionvirus infectionvirus-induced disease
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Description preview
It is appreciated that the high prevalence of asthma over the last decades reflects the interaction of susceptibility
genes in affected individuals with environmental and social changes ushered by modernity [1]. A key feature of
asthma is chronic airway inflammation driven and/or exacerbated by ongoing exposure to allergens and
pollutants, most…
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