grant
Genetic and Environmental Modifiers Of Autoimmune Disease
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025ArthritisAutoantibodiesAutoimmuneAutoimmune DiseasesCollaborationsDevelopmentDiabetes MellitusDiseaseDisorderEnvironmental FactorEnvironmental Risk FactorFutureGenesGeneticGoalsHumanIgG ReceptorsImmune responseImmunoglobulin G ReceptorInfectionInvestigationLinkLupusLupus Erythematosus DisseminatusMalariaMethodsMiceMice MammalsModern ManMolecularMurineMusNIAIDNational Institute of Allergy and Infectious DiseaseOther GeneticsPaludismPathogenicityPathologyPathway interactionsPatientsPlasmodium InfectionsPredispositionResearchSLESusceptibilitySystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTLR7TLR7 geneTherapeuticToll-Like Receptor 7Viralarthriticautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodyclinical riskdevelopmentaldiabetesdisseminated lupus erythematosuseffective therapyeffective treatmentenvironmental riskfitnessgamma Fc Receptorshost responseimmune system responseimmunoresponseinsightmalaria infectionmalaria-infectedmalarial infectionmembermouse modelmurine modelpathwaypressureprogramsself reactive antibodysensorsystemic autoimmune diseasesystemic autoimmune disordersystemic lupus erythematosisviral RNAvirus RNAwork groupworking group
Description preview
The main focus of our group is the identification of characterization of genes and environmental factors that contribute to the development of systemic autoimmune disease. We use mouse models of systemic lupus erythematosus (SLE) to determine the necessity of certain molecular pathways and cellular interactions in the spontaneous autoimmune…
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