grant
Genetic Analysis of T-cell Differentiation
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAffinityAgingAgonistAntigen PresentationAntigen ReceptorsAntigen TargetingAntigensBasal Transcription FactorBasal transcription factor genesBindingBiochemicalBlood leukocyteBlood monocyteBody TissuesBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer PatientCas nuclease technologyCause of DeathCell BodyCell CommunicationCell Communication and SignalingCell Death InductionCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell Surface GlycoproteinsCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChromatinClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComputer AnalysisDNA mutationDNA-Binding ProteinsDeathDevelopmentEpitheliumExperimental NeoplasmsExperimental TumorGametesGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGerm CellsGerm-Line CellsHIVHistocompatibility ComplexHistocompatibility ComplicesHumanHuman Immunodeficiency VirusesImmune responseImmune systemImmunofluorescenceImmunofluorescence ImmunologicImmunologyImpairmentInfectionIntracellular Communication and SignalingLAV-HTLV-IIILYT3LaboratoriesLactationLeukocytesLeukocytes Reticuloendothelial SystemLifeLigandsLong-term infectionLymphadenopathy-Associated VirusLymphatic cellLymphocyteLymphocyticMacrophageMajor Histocompatibility ComplexMajor Histocompatibility ComplicesMammary glandMapsMarrow TransplantationMarrow leukocyteMarrow monocyteMembrane GlycoproteinsModelingModern ManMolecularMolecular InteractionMorbidityMorbidity - disease rateMutant Strains MiceMutationMyeloablative ChemotherapyMyeloid CellsMφOrganPeptidesProcessPropertyProtein AnalysisPubertyPublicationsRNA ExpressionReproductive CellsResearchRoleScientific PublicationSex CellShapesSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSurfaceSurface GlycoproteinsT cell differentiationT cell responseT-Cell DepletionT-Cell DevelopmentT-Cell OntogenyT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-Lymphocyte SubsetsT-cell depletion therapyT-lymphocyte depletion therapyT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesThymocyte DevelopmentThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTumor AntigensTumor-Associated AntigenVirus-HIVWhite Blood CellsWhite CellWorkZinc Finger DomainZinc Finger MotifsZinc Fingersanalyze gene expressionantigen bindingantigen boundbiological signal transductioncancer antigenscell mediated immune responsecell typechronic infectioncomputational analysescomputational analysiscomputer analysesdevelopmentaldimerfightinggene expression analysisgene expression assaygene regulatory networkgenetic analysisgenome editinggenome mutationgenomic editinghost responsehypoimmunityimmune deficiencyimmune system responseimmunodeficiencyimmunogenimmunoresponsein vivoinfection recurrenceinitial cellinterestintraepitheliallab assignmentlab experimentlaboratory activitylaboratory assignmentlaboratory exerciselaboratory experimentlactatinglactationallymph celllymphocyte precursorlymphocyte progenitorlymphocyte stem celllymphoid precursorlymphoid progenitorslymphoid stem cellmonocytemortalitymouse mutantnovelpersistent infectionpro-apoptotic proteinprogramsprotein functionrecurrent infectionrecurring infectionresponsescATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsexual cellsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolethymocytethymus derived lymphocytetranscription factortranscriptional profilingtranscriptomicstumortumor-specific antigenwhite blood cellwhite blood corpuscle
Description preview
We study T lymphocytes (T cells), white blood cells essential for immune responses. Most express an antigen receptor (TCR) comprising a dimeric alpha-beta antigen-binding subunit (ab T cells) and recognize peptide antigens presented by class I (MHC-I, HLA A, B, and C in humans) or class II (MHC-II, HLA DP, DQ and DR in humans) classical Major…
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