grant
Generation of Pan-reactive Antibody and Cytokine Reagents for Immunologic Analysis of Bats
Organization INTEGRAL MOLECULARLocation PHILADELPHIA, UNITED STATESPosted 19 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAntibodiesAntigenic DeterminantsB-Cell EpitopesB-Lymphocyte EpitopesB7-1BB1BacteriophagesBatsBindingBinding DeterminantsBp35CD11bCD20CD28LGCD28LG1CD3CD3 AntigensCD3 ComplexCD3 moleculeCD56CD62LCD8CD80CD80 geneCD8BCD8B1CD8B1 geneCR3ACatalogsCell BodyCell surfaceCellsChickensChiropteraClinical TrialsCo-StimulatorCommunitiesContracting OpportunitiesContractsCostimulatorCross ReactionsDevelopmentDiseaseDisorderEbolaEpidermal Thymocyte Activating FactorEpitopesFamilyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrankfurt-Marburg Syndrome VirusGallus domesticusGallus gallusGallus gallus domesticusGenerationsGenetic DifferentiationGenetic DivergenceGenetic DriftGoalsHLHRCHendraIL-2IL2 ProteinITGAMITGAM geneImmuneImmune TargetingImmune responseImmunesImmunizationImmunoblottingImmunochemical ImmunologicImmunofluorescenceImmunofluorescence ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyIndustryInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-2Interleukine 2Interleukine 2 PrecursorInterleukine IILAB7LAM-1 geneLECAM1LNHRLSELLYAM-1LYAM1LYT3Leu-16Lipid BilayersLymphocyte Mitogenic FactorMAC1AMERSMERS coronavirus diseaseMERS-CoV diseaseMO1AMS4A1MS4A1 geneMS4A2Mammalian CellMarburgMarburg virusMarburg-like VirusesMarburgvirusMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiddle East Respiratory SyndromeMiddle East Respiratory Syndrome CoV diseaseMiddle East Respiratory Syndrome coronavirus diseaseMiddle Eastern Respiratory SyndromeMiddle Eastern Respiratory Syndrome CoV diseaseMiddle Eastern Respiratory Syndrome coronavirus diseaseMitogenic FactorMolecularMolecular InteractionNCAMNCAM1NCAM1 geneNIAIDNational Institute of Allergy and Infectious DiseaseNipahOKT3 antigenOrthologOrthologous GeneOrthomarburgvirusPhage DisplayPhagesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductionProtein EngineeringProtein ModificationProtein SecretionProteinsProteomeProtocolProtocols documentationRNA immunizationRNA vaccinationRabiesReagentReporterResearchRousettusSARSSARS coronavirus diseaseSARS-CoV diseaseSELL geneSelectin L GeneServicesSevere Acute Respiratory SyndromeSevere Acute Respiratory Syndrome CoV diseaseSevere Acute Respiratory Syndrome coronavirus diseaseSpecificityStructureSurface ProteinsSystemT cell growth factorT-Cell Growth FactorT-Cell Stimulating FactorT3 AntigensT3 ComplexT3 moleculeTQ-1TechnologyTestingTherapeuticThymocyte Stimulating FactorVirionVirusVirus ParticleVirus-like particleWestern BlottingWestern ImmunoblottingWorkYinbacterial viruscatalogcell typecross reactivitycytokinedevelopmentalflow cytophotometrygenetic protein engineeringhost responseimmune system responseimmunocytochemistryimmunoresponselipid bilayer membranelyssamRNA immunizationmRNA vaccinationmembrane structuremodel of animalprogramsprotein blottingprotein designprotein functionresponsesuccessviral disease outbreakviral outbreakvirus disease outbreakvirus-like nanoparticlesviruslike particle
Description preview
ABSTRACT
Understanding the immune response in bats can aid in the response to viral outbreaks and other diseases, but
the bat research community suffers from a scarcity of immunologic research reagents. The remarkably high
divergence among bat species makes the development of cross-reactive MAbs and cytokine reagents
especially difficult. However,…
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